孙先宝，副研究员，硕士生导师。1989年生，安徽金寨人。2011年本科毕业于安徽大学，2019年博士毕业于中国科学技术大学，同年加入东南大学生物科学与医学工程学院开展博士后研究（合作导师：梁高林教授）。2025年3月留校任职。迄今以第一/通讯（含共同）作者身份在J. Am. Chem. Soc.、Adv. Sci.等国际权威期刊发表论文22篇，其中JCR一区论文13篇，影响因子≥10论文9篇。主持国家级项目1项（国家自然科学青年基金）、省部级科研项目3项（“博新计划”、博士后面上项目第67批和第73批）以及校级项目2项；作为骨干成员参与国家重点研发计划等国家级重大项目多项。
研究方向：
1. 多靶标激活的肿瘤/疾病精准成像诊断策略；
2. 基于多肽材料/水凝胶的药物智能控释体系。
近期部分代表论文（#共同一作，*通讯作者）：
(1) Penghao Zhen#, Qiaochu Jiang#, Fuchao Yu, Xuan Xu, Qin Wei, Xiaoyang Liu, Xianbao Sun*, Gaolin Liang*, Jiayi Tong*. ROS-differentiated release of Apelin-13 from hydrogel comprehensively treats myocardial ischemia-reperfusion injury. Journal of Controlled Release, 2025, 379, 609-620. (JCR Q1)
(2) Haisi Wu#, Xianbao Sun#, Kaiming Li#, Jinyu Li#, Hui Jiang#, Dan Yan, Ya Lin, Yan Ding, Yawen Lu, Xiaole Zhu, Xufeng Chen*, Xiaolin Li*, Gaolin Liang*, Huae Xu*. Pyruvate Kinase M2-Responsive Release of Paclitaxel and Indoleamine 2,3-Dioxygenase Inhibitor for Immuno-Chemotherapy of Nonsmall Cell Lung Cancer.Advanced Science, 2025, 12, 2409790. (JCR Q1)
(3) Xianbao Sun, Lingling Xu, Hai-Dong Xu, Limin Xie,Rui Wang, Zhimou Yang, Wenjun Zhan, Shurong Shen*, Gaolin Liang*. Intracellular Nitroreductase-Triggered “On” and “Enhanced” Photoacoustic Signals for Sensitive Imaging of Tumor Hypoxia. Advanced Healthcare Materials,2024, 13, 2303472. (JCR Q1)
(4) Xianbao Sun, Manli Wang, Xiaoyang Liu, Wenjun Zhan, Guangqiong Xu, Qiaochu Jiang, Hai-Dong Xu, Fuqiang Wang*, Gaolin Liang*. Enzymatic self-assembly/disassembly turns “ON”/“OFF” the mimetic hydrolytic activity of histidine nanofibers. Science China Chemistry, 2024, 67, 517-522. (JCR Q1)
(5) Xianbao Sun, Lingling Xu, Xiaoyang Liu, Hai-Dong Xu, Wenjun Zhan, Gaolin Liang*. Activatable small molecular luminescence probes for autofluorescence-free bioimaging. Trends in Analytical Chemistry,2023, 168, 117326. (JCR Q1)
(6) Xianbao Sun, Tiantian Xia, Lingling Xu, Wenjun Zhan, Gaolin Liang*. Facile Label-Free Three-Input Molecular Keypad Lock. Analytical Chemistry, 2023, 95, 5839–5842. (JCR Q1)
(7) Ge Gao#, Xianbao Sun#, Xiaoyang Liu, Runqun Tang, Manli Wang, Wenjun Zhan, Junnian Zheng*, Gaolin Liang*. FAP-α-Instructed Coumarin Excimer Formation for High Contrast Fluorescence Imaging of Tumor. Nano Letters, 2022, 22, 6782-6786. (JCR Q1)
(8) Ge Gao#, Xianbao Sun#, Xiaoyang Liu, Yao-Wen Jiang, Runqun Tang, Yuxin Guo, Fu-Gen Wu*, Gaolin Liang*. Intracellular Nanoparticle Formation and Hydroxychloroquine Release for Autophagy-Inhibited Mild-Temperature Photothermal Therapy for Tumors. Advanced Functional Materials, 2021, 31, 2102832. (JCR Q1)
(9) Ge Gao, Xianbao Sun*, Gaolin Liang*. Nanoagent-Promoted Mild-Temperature Photothermal Therapy for Cancer Treatment. Advanced Functional Materials, 2021, 31, 2100738. (JCR Q1)
(10)Xianbao Sun, Bing Wei, Yijun Guo, Shiyan Xiao*, Xiang Li, Dongbao Yao, Xue Yin, Shiyong Liu, Haojun Liang*. A Scalable “Junction Substrate” to Engineer Robust DNA Circuits. Journal of the American Chemical Society, 2018, 140, 9979-9985. (JCR Q1)
欢迎感兴趣的同学联系攻读硕士学位，专业包括但不限于生物医学工程、分析化学、有机化学、材料、药学等！
邮箱：xbsun@seu.edu.cn
地址：东南大学九龙湖校区生医楼1009室