吕晓迎

发布者：刘丽发布时间：2013-01-23浏览次数：28400


吕晓迎、女、1956年5月生，二级教授、博导，邮箱：luxy@seu.edu.cn

办公室电话：025-83793430

学校及社会任职情况：

  • 中国生物材料学会（国家一级学会）理事

  • 中国生物医学工程学会生物材料分会常务理事

  • 中国生物医学工程学会神经工程分会第一届理事（2010-2014）

  • 中国生物材料学会纳米生物材料分会理事

  • 中华口腔医学会口腔材料专业委员会第一届至第四届常务理事（1998-2014），第五届、第六届理事（2015-）

  • 中国机械工程学会表面工程分会生物材料表面工程专委会理事

  • 中国微米纳米技术学会纳米科学技术分会纳米生物材料专业委员会理事

  • 中国生物材料学会生物陶瓷分会理事

  • 江苏省口腔医学会理事

  • 江苏省侨联常委

  • 东南大学侨联主席

教育背景：

1980年毕业于上海第二医科大学，后在上海第九人民医院任口腔科医生和生物材料研究室从事生物材料生物相容性工作。1986年在上海第二医科大学获医学硕士学位，1996年于德国弗莱堡大学获德国牙科医学博士学位，1996-1997在该校做博士后研究。

研究方向：

  1. 生物材料与生物相容性

    • 生物材料与蛋白质相互作用研究(分子相容性新技术新方法)

    • 基于多层次生物组学和生物信息学的生物医用材料与细胞相互作用机理研究

    • 基于高通量技术的生物材料对机体作用的生物标志物研究

  2. 生物电子学

    • 新型医用有源植入式装置（微电子神经桥等）研制

    • 基于微电子阵列的神经芯片/脑芯片的神经元网络信号传递和药物筛选

    • 基于穴位功能电刺激的瘫痪肢体功能重建

研究成果、获奖情况、代表性著作论文

  • 研究成果：1997年回国后主持和参加了教育部项目、国家自然科学基金面上和重大项目以及973计划、863计划项目等40多项。在Biomaterials、Acta Biomaterialia等国内外学术期刊和会议上发表论文380余篇，SCI、EI、ISTP收录150多篇次，连续五年（2014-2018年）入选中国高被引学者（Most Cited Chinese Researchers）榜单（生物医学工程领域），2017年被评为科学中国人（2016）年度人物。申请专利40项，授权专利35项（含国际发明专利一项）。

  • 获奖情况

    1. 1987年获卫生部科学技术进步三等奖（医用热硫化甲基乙烯基硅橡胶质量标准）

    2. 1995年获国家教委科学技术进步三等奖（体外细胞培养评价生物材料安全性的系列研究）

    3. 2008年获浙江省科学技术奖二等奖（生物材料生物相容性的分子生物学评价研究）

    4. 2011年获2010年中华医学科技奖二等奖（医疗器械生物学评价标准和试验方法建立及应用）

    5. 2013年获江苏侨界贡献奖（创新成果）（生物材料分子生物学评价新方法与植入式神经微电子器件）

    6. 2014年获中国侨界贡献奖（创新成果）（微电子神经/肌电桥在瘫痪肢体运动功能康复中的应用）

    7. 2015年获日内瓦国际发明展医学组特别金奖（微电子神经肌电桥）

    8. 2018年江苏省教育教学与研究成果奖三等奖（研究类）（基于脊髓内微刺激的瘫痪下肢运动功能重建研究）

  • 代表性论文

    1. Xiaoying Lü*, Xiang Bao, Yan Huang, et al. Mechanisms of cytotoxicity of nickel ions based on gene expression profiles. Biomaterials, 2009, 30(2): 141-148. （SCI，影响因子8.806，EI）

    2. Lü Xiaoying*, Lu Huiqin, Zhao Lifeng, et al. Genome-wide pathways analysis of nickel ion-induced differential genes expression in fibroblasts. Biomaterials, 2010, 31(8):1965-1973（SCI，影响因子8.806，EI）

    3. Yan Cui, Yuyun Zhao, Yue Tian, Wei Zhang*, Xiaoying Lü*, et al. The molecular mechanism of action of bactericidal gold nanoparticles on Escherichia Coli. Biomaterials, 2012, 33:2327-2333. （SCI，影响因子8.806）

    4. Dayun Yang, Xiaoying Lü*, Ying Hong, et al. The molecular mechanism of mediation of adsorbed serum proteins to endothelial cells adhesion and growth on biomaterials. Biomaterials, 2013, 34: 5747-5758.（SCI，影响因子8.806，EI）

    5. Dayun Yang, Xiaoying Lü*, Ying Hong, et al. The molecular mechanism for effects of TiN coating on NiTi alloy on endothelial cell function. Biomaterials, 2014, 35:6195-6205.（SCI，影响因子8.806，EI）

    6. Yan Huang, Xiaoying Lü*, Yinghua Qu, et al. MicroRNA sequencing and molecular mechanisms analysis of the effects of gold nanoparticles on human dermal fibroblasts. Biomaterials 2015,37:13-24（SCI，影响因子8.806，EI）

    7. Yan Huang, Xiaoying Lü*, Weiping Qian, et al. Competitive protein adsorption on biomaterial surface studied with reflectometric interference spectroscopy. Acta Biomaterialia, 2010,6(6):2083-2090（SCI，影响因子6.383）

    8. Yamin Yang, Yinghua Qu, Xiaoying Lü*. Global gene expression analysis of the effects of gold nanoparticles on human dermal fibroblasts. Journal of Biomedical Nanotechnology, 2010, 6:234-246.（SCI，影响因子5.068，EI）

    9. Jingwu Ma, Lü Xiaoying*, Yan Huang. Genomic analysis of cytotoxicity response to nanosilver in human dermal fibroblasts. Journal of Biomedical Nanotechnology, 2011, 7(2): 263-275.（SCI，影响因子5.068，EI）

    10. Yinghua Qu, Yan Huang, Xiaoying Lü*. Proteomic analysis of molecular biocompatibility of gold nanoparticles to human dermal fibroblasts-fetal. Journal of Biomedical Nanotechnology, 2013, 9(1): 40-52. （SCI，影响因子5.068）

    11. Yan Huang, Xiaoying Lü*, Jingwu Ma. Toxicity of Silver Nanoparticles to Human Dermal Fibroblasts on MicroRNA Level. Journal of Biomedical Nanotechnology, 2014, 10(11), 3304-3317.（SCI，影响因子5.068，EI）

    12. Yadong Yu, Xiaoying Lü*, Fei Ding. Influence of poly(L-lactic acid) aligned nanofibers on PC12 differentiation. Journal of Biomedical Nanotechnology, 2015,11(5), 816-827.（SCI，影响因子5.068，EI）

    13. Fei Yang, Yadong Yu, Xiaoying Lü*. A systematic study of plla aligned nanofiber-induced differentiation of PC12 cell using mRNA-microRNA-protein biomics integrated analyses. Journal of Biomedical Nanotechnology 2017,13(10): 1045-1057.（SCI，影响因子5.068）

    14. Yan Huang, Xiaoying Lü*, Xiaoying Lü. Study of key biological pathways and important microRNAs involved in silver nanoparticles induced cytotoxicity based on microRNA sequencing technology. Journal of Biomedical Nanotechnology, 2018,14: 2042-2055（SCI，影响因子5.068）

    15. Huang Yan, Lü Xiaoying*, Ma Jingwu, Huang Nan. In vitro investigation of protein adsorption and platelet adhesion on inorganic biomaterial surfaces. Applied Surface Science, 2008, 255(2): 257-259.（SCI，影响因子4.439，EI）

    16. Zong-Hao Huang, Zhi-Gong Wang*, Xiao-ying Lü, et al.The principle of the micro-electronic neural bridge and a prototype system design. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 2016, 24:180-191（SCI，影响因子3.972）

    17. Yadong Yu, Xiaoying Lü*, Fei Ding. MicroRNA regulatory mechanism by which PLLA aligned nanofibers influence PC12 cell differentiation. Journal of Neural Engineering, 2015,12(4):046010.（SCI，影响因子3.92，EI）

    18. Zhou Yu-Xuan, Wang Hai-Peng, Bao Xue-Liang, Lü Xiaoying *, Wang, Zhi-Gong*. A frequency and pulse-width co-modulation strategy for transcutaneous neuromuscular electrical stimulation based on sEMG time-domain features. Journal of neural engineering, 2016, 13(1):016004（SCI，影响因子3.92，EI）

    19. Lü Xiaoying*, Huang Yan, Qian Weiping, et al. An effective method for quantitative evaluation of proteins adsorbed on biomaterial surfaces. Journal of Biomedical Materials Research: Part A, 2003, 66A(3):722-727.（SCI，影响因子3.231，EI）

    20. Xiaoying Lü*, Jiandan Wang, Bin Li, et al. Gene expression profile study on osteoinductive effect of natural hydroxyapatite. Journal of Biomedical Materials Research: Part A, 2014, 102,2833-2841（SCI，影响因子3.231，EI）

    21. Y.Z. Chen, X.Y. Lü*, G.D. Liu. A novel root-end filling material based on hydroxyapatite, tetracalcium phosphate and polyacrylic acid. International Endodontic Journal, 2013,46(6): 556-564,（SCI，影响因子3.015）

    22. Lü Xiaoying*, Li Dejun, Huang Yan, et al. Application of a modified Coomassie brilliant blue protein assay in study of protein adsorption on carbon thin films. Surface and Coatings Technology, 2007,201(15):6843-6846. (SCI，影响因子2.906，EI)

    23. Xiao-Jun Tang, Lai Gui*, Xiao-Ying Lü.Hard tissue compatibility of natural hydroxyapatite/chitosan composite. Biomedical Materials, 2008, 3(4): 44115.（SCI，影响因子2.897，EI）

    24. Xiaoying Lü*, Wei Cui, Yan Huang, et al. Surface modification on silicon with chitosan and biological research. Biomedical Material, 2009,4: 044103.（SCI，影响因子2.897，EI）

    25. Zhao Yi, Lü Xiao Ying*, Wang Zhigong, et al. Study of the adhesion improvement in hippocampal cells on collagen/chitosanmodified silicon surfaces. Biomedical Material, 2009, 4:065004.（SCI，影响因子2.897，EI）

    26. Yinghua Qu, Xiaoying Lü*. Aqueous synthesis of gold nanoparticles and their cytotoxicity in human dermal fibroblasts–fetal. Biomedical materials, 2009, 4: 025007.（SCI，影响因子2.897，EI）

    27. Zhao Lifeng, Hong Yan, Yang Dayun, Lü Xiaoying*, et al. The underlying biological mechanisms of biocompatibility differences between bare and TiN-coated NiTi alloys. Biomedical Materials, 2011, 6, 025012.（SCI，影响因子2.897，EI）

    28. Zhiwei Zhang, Jiandan Wang, Xiaoying Lü*. An integrated study of natural hydroxyapatite-induced osteogenic differentiation of mesenchymal stem cells using transcriptomics, proteomics and microRNA analyses. Biomedical Materials, 2014, 9: 045005.（SCI，影响因子2.897，EI）

    29. Xueliang Bao, Yuxuan Zhou, Yunlong Wang, Jianjun Zhang, Xiao-Ying Lü*, Zhigong Wang*. Electrode placement on the forearm for selective stimulation of finger extension/flexion. PLOS ONE, 2018, 13(1): e0190936.（SCI，影响因子2.766）

    30. Chen Yao-Zhong, LüXiao-Ying*, Liu Gen-Di. Effects of different radio-opacifying agents on physicochemical and biological properties of a novel root-end filling material. PLOS ONE, 2018, 13(2): e0191123.（SCI，影响因子2.766）

    31. Wang Yufeng, Wang Zhigong*, Lü Xiaoying, et al. A multichannel neural signal detecting module: Its design and test in animal experiments. Progress in Natural Science, 2007, 17(6): 675-680.（SCI，影响因子2.572，EI）

    32. Zhigong Wang*, Xiaosong Gu, Xiaoying Lü, et al. Microelectronics-embedded channel bridging and signal regeneration of injured spinal cords. Progress in Natural Science, 2009,19:1261-1269.（SCI，影响因子2.572）

    33. Xiaoyan Shen, Zhigong Wang*, Xiaoying Lv, et al. Microelectronic neural bridging of toad nerves to restore leg function. Neural Regeneration Research, 2013;8(6):546-553.（SCI，影响因子2.234）

    34. Zonghao Huang, Zhigong Wang*, Xiaoying Lv, et al. A novel functional electrical stimulation-control system for restoring motor function of post-stroke hemiplegic patients. Neural Regeneration Research, 2014, 9(23):2102-2110（SCI，影响因子2.234）

    35. Hai-peng Wang, Zheng-yang Bi, Yang Zhou, Yu-xuan Zhou, Zhi-gong Wang*, Xiao-ying Lv. Real-time and wearable functional electrical stimulation system for volitional hand motor function control using the electromyography bridge method. Neural Regeneration Research, 2017,12(1): 133-142.（SCI，影响因子2.234）

    36. Shuai An, Yong-Fang Zhao, Xiao-Ying Lü*, Zhi-Gong Wang*. Quantitative evaluation of extrinsic factors influencing electrical excitability in neuronal networks: Voltage Threshold Measurement Method (VTMM). Neural Regeneration Research, 2018, 13(6): 1026-1035.（SCI，影响因子2.234）

    37. Haixian Pan, Xiaoying Lü*, Zhigong Wang*, et al. Silicon-based microelectrode arrays for stimulation and signal recording of in vitro cultured neurons. Science in China Series F-Information Sciences, 2011, 54(10): 2199-2208.（SCI，影响因子2.188）

    38. Yu-Xuan Zhou, Yang Xia, Jia Huang, Hai-Peng Wang, Xue-Liang Bao, Zheng-Yang Bi, Xiao-Bing Chen, Yu-Jie Gao, Xiaoying Lü*, Zhi-Gong Wang*. Electromyographic bridge for promoting the recovery of hand movements in subacute stroke patients: a randomized controlled trial. Journal of Rehabilitation medicine, 2017, 49(8):629-636 （SCI，影响因子1.802）

    39. LI DeJun, YUAN Li, YANG Ying, DENG XiangYun, LÜ XiaoYing, et al. Adsorption and adhesion of blood proteins and fibroblasts on multi-wall carbon nanotubes. Science in China Series C: Life Sciences, 2009, 52 (5): 479-482（SCI，影响因子1.61）

    40. Yadong Yu, Xiaoying Lü*, Fei Ding. The role of integrins in poly(L-lactic acid) aligned nanofiber-PC12 cell interaction revealed by mRNA-microRNA profile integrative analysis. Science of Advanced Materials. 2014, 6(8), 1919-1926（SCI，影响因子1.318）

    41. Yan Huang, Xiaoying Lü*. The influence of silver nanoparticle-induced oxidative stress on microRNA expression and cytotoxicity. Science of Advanced Materials. 2014, 6(8), 1907-1918（SCI，影响因子1.318）

    42. Zhiwei Zhang, Xiaoying Lü*. A comparative study of the impact of natural and synthetic hydroxyapatite on mesenchymal stem cell function based on proteomics. Science of Advanced Materials, 2015,7(8):1611-1623（SCI，影响因子1.318）

    43. Lü XY*, Zheng BZ, Tang XJ, et al. In vitro biomechanical and biocompatible evaluation of natural hydroxyapatite/chitosan composite for bone repair. Journal of Applied Biomaterials and Biomechanics, 2011, 9(1): 11-18.（SCI，影响因子1.16）

    44. Hai-Peng Wang, Ai-Wen Guo, Yu-Xuan Zhou, Yang Xia, Jia Huang, Chong-Yao Xu, Zong-Hao Huang, Xiao-Ying Lü, Zhi-Gong Wang*. A wireless wearable surface functional electrical stimulator. International Journal of Electronics, 2017, 104(9): 1514-1526（SCI，影响因子0.939，EI）

    45. Wanjun Tao, Fei Li, Chenhao Wang, Guiming Tu, Zhigong Wang*, Xiaoying Lü*. Design of integrated neural stimulating and recording frontend for bladder control prosthesis. Analog Integrated Circuits And Signal Processing, 2017, 91(3): 403-416（SCI，影响因子0.8，EI）

    46. 吕晓迎*,黄炎,俞亚东等. 基因/蛋白质组学技术在生物材料生物相容性研究中的应用. 无机材料学报，2013,28(1):21-28.（SCI，影响因子0.49）

    47. 赵梦鲤,岳玉琛,袁丽,李德军*,吕晓迎等. 成纤维细胞和血小板在多壁碳纳米管上粘附性. 无机材料学报, 2011,26(1):73-77.（SCI，影响因子0.49）

    48. Xiaoying Lü*, Yayun Qu, Ying Hong, et al. A high-throughput study for endothelial cell adhesion and growth mediated by adsorbed serum protein via signaling pathway PCR array. Regenerative Biomaterials, 2018,5(1): 25-34.（SCI）

    49. Xiaoying Lü*, Heng Zhang, Yan Huang, et al. A proteomics study to explore the role of adsorbed serum proteins for PC12 cell adhesion and growth on chitosan and collagen/chitosan surfaces. Regenerative Biomaterials, 2018, 5(5):261-273（SCI）

    50. Xiaoying Lü*, Fei Yang, Yan Huang, et al. Role of integrin in influencing differentiation of PC12 cell grown on PLLA aligned nanofiber: A mRNA-microRNA-protein integrative study. Regenerative Biomaterials, 2017, 4(2):89-96.（SCI）

  • 参编专著

    1. Xiaoying Lü, Yan Huang. 《Silver Nanoparticles for Antibacterial Devices: Biocompatibility and Toxicity》第10章“Evaluating the interactions of silver nanoparticles and mammalian cells based on biomics technologies”，英国CRC出版社，2017年。

    2. Zhigong Wang, Xiaoying Lü,Boshuo Wang. 《Recent Progresses in Bioelectronics》第9章“Dection, Processing, and Application of Neural Signals”，科学出版社，2016年。