谢芃

发布者:张怡茹发布时间:2023-03-27浏览次数:7673



谢芃,东南大学生物科学与医学工程学院,江苏省南京市玄武区四牌楼2号,210096pengx@seu.edu.cn

  

研究方向:

运用生物信息学与人工智能方法,通过多模态数据融合,探究发育生物学、神经生物学中的细胞命运决定与调控过程。

 

工作经历:

2022.08至今:       研究员,东南大学生物科学与医学工程学院

2019.08-2022.08     助理研究员,东南大学脑科学与智能技术研究院

2018.07-2019.07:     数据科学家,Allen Institute for Brain Science

 

教育经历:

2006.08-2010.07    清华大学,数学物理基础科学专业,学士

2010.08-2013.06:    清华大学,控制科学与工程专业,硕士

2014.08-2018.05    美国德克萨斯大学达拉斯分校,分子与细胞生物学,博士


在研基金:

国家重点研发计划,2019-2024年(胚胎心脏前体细胞的精确定位与命运决定机制,参与)

国家自然科学基金青年基金项目,2022-2024年(神经元完整形态分类方法开发,项目负责人)

江苏省重症医学重点实验室自主课题,2022-2023年(多器官功能障碍综合征基因组与临床信息大数据平台的构建,课题负责人)


发表论文:

(* 共同第一作者; † 共同通讯作者)

  1. 1.      Jiaxin Wu*, Juan Li*, Kang Chen*, Guolong Liu*, … Peng Xie, Tao P. Zhong. Atf7ip and Setdb1 interaction orchestrates the hematopoietic stem and progenitor cell state with diverse lineage differentiation. PNAS. Doi: 10.1073/pnas.2209062120. (2022)

  2. 2.      Hanchuan Peng*, Peng Xie*, Lijuan Liu*, et al. Morphological diversity of single neurons in molecularly defined cell types. Nature. doi: 10.1038/s41586-021-03941-1. (2021)

  3. 3.      Muñoz-Castañeda, R., Zingg, B., Matho, K.S., … Peng Xie, et al. Cellular anatomy of the mouse primary motor cortex. Nature. doi: 10.1038/s41586-021-03970-w. (2021)

  4. 4.      BRAIN Initiative Cell Census Network (BICCN, Peng Xie as co-author). A multimodal cell census and atlas of the mammalian primary motor cortex. Nature. doi: 10.1038/s41586-021-03950-0. (2021)

  5. 5.      Lei Qu*, Yuanyuan Li*, Peng Xie, et al. Cross-Modality Coherent Registration of Whole Mouse Brains. Nature Methods. doi: 10.1038/s41592-021-01334-w. (2021)

  6. 6.      Chenghao Guo, Zhuanzhuan Che, Junjie Yue, Peng Xie, et al. ENL initiates multivalent phase separation of the super elongation complex (SEC) in controlling rapid transcriptional activation. Science Advances. doi: 10.1126/sciadv.aay4858. (2020)

  7. 7.      Peng Xie*, Mingxuan Gao*, Chunming Wang, Jianfei Zhang, Pawan Noel, Chaoyong Yang, Daniel Von Hoff, Haiyong Han, Michael Q Zhang, Wei Lin. SuperCT: A supervised-learning framework for enhanced characterization of single-cell transcriptomic profiles. Nucleic Acids Research. doi: 10.1093/nar/gkz116. (2019)

  8. 8.      Yoon Jung Kim*, Peng Xie*, Lian Cao, Michael Q. Zhang† and Tae Hoon Kim†.Global transcriptional activity dynamics reveal functional enhancer RNAs. Genome Research. doi: 10.1101/gr.233486.117. (2018)

  9. 9.      Fei Xavier Chen, Peng Xie, Clayton K. Collings, Kaixiang Cao, Yuki Aoi, Stacy A. Marshall, Emily J. Rendleman, Michal Ugarenko, Patrick A. Ozark, Anda Zhang, Ramin Shiekhattar, Edwin R. Smith, Michael Q. Zhang, Ali Shilatifard. PAF1 regulation of promoter-proximal pause release via enhancer activation.  Science. doi: 10.1126/science.aan3269. (2017)

  10. 10.   Chen Jia, Peng Xie, Min Chen†, Michael Q. Zhang†. Stochastic fluctuations can reveal the characteristics of feedback loop of auto-regulatory gene networks at the single-molecule level. Sci. Reports. doi:10.1038/s41598-017-15464-9.(2017)

  11. 11.   Celeste B. Greer, Yoshiaki Tanaka, Yoon Jung Kim, Peng Xie, Michael Q. Zhang, In-Hyun Park and Tae Hoon Kim. Histone deacetylases positively regulate transcription through the elongation machinery. Cell Reports. doi: 10.1016/j.celrep.2015.10.013. (2015).

  12. 12.   Ye Yuan*, Bing Liu*, Peng Xie, Michael Q. Zhang, Yanda Li, Zhen Xie†, Xiaowo Wang†. Model-guided quantitative analysis of microRNA-mediated regulation on competing endogenous RNAs using a synthetic gene circuit. PNAS. doi: 10.1073/pnas.1413896112. (2015)

  13. 13.  Peng Xie*, Yu Liu*, Yanda Li, Michael Q. Zhang† and Xiaowo Wang†. MIROR: a method for cell-type specific microRNA occupancy rate prediction.Mol Biosyst. doi: 10.1039/c3mb70610a. (2014)