林凤鸣

发布者:张怡茹发布时间:2020-09-04浏览次数:7437




林凤鸣,东南大学生命科学与医学工程院,教授,博士生导师。主要从事合成生物、系统生物学、生物医用材料等领域的研究。至今在Small Structure, ACS Applied Materials & InterfacesmBioNanoscaleBiotechnology for Biofuel等杂志发表SCI论文53篇,其中通讯/一作41篇,发表文章总引用次数1700多次。授权专利7项。主持国家自然科学青年基金和面上项目基金。参与973863等重大科技项目多项。目前的主要研究方向有1)微生物转录水平调控机理研究;(2)真菌非经典分泌途径的研究;(3)碳点的合成和应用;(4)抗菌抗癌纳米药物研发。


工作教育经历

2023/4-至今,  东南大学,      生医学院,    教授

2014/9-2023/4  东南大学,      生医学院,    副教授

2011/9-2014/8, 美国密歇根大学,化工系和化学系,博士后

2005/9-2011/6,天津大学,  制药工程,   博士,元英进 。  

2009/9-2011/6,美国密歇根大学, 化学工程系, 联合培养 Xiaoxia Nina Lin

2001/9-2005/9,天津大学, 制药工程,   学士。

 

每年拟招收博士后,博士生1名,硕士生3名,本科毕业设计3名。希望生物医学工程、医学、生物、材料等专业的学生踊跃报考。联系方式:linfengming@seu.edu.cn

 

已发表的论文

(1)      Ai-Ping Pang, Haiyan Wang, Yongsheng Luo, Funing Zhang, Fu-Gen Wu, Zhihua Zhou, Zuhong Lu*, Fengming Lin*. Investigating the cellular functions of 𝛽-glucosidases for synthesis of lignocellulose-degrading enzymes in Trichoderma reesei, Engineering Microbiology, 2023, 3, 1005.

(2)      Haiyan Wang, Ai-Ping Pang, Bingzhi Li, Liujie Huo, Fu-Gen Wu, Fengming Lin*. Intracellular sugar transporters facilitate cellulase synthesis in Trichoderma reesei using lactose. Biomolecules, 2023, 13, 295.

(3)      Zihuayuan Yang, Jie Zhang, Fu-Gen Wu, Fengming Lin*. Structural characterization, functional profiling, and mechanism study of four antimicrobial peptides for antibacterial and anticancer applications. Langmuir 2023, 39, 2161−2170.

(4)      Samran Durrani, Jie Zhang, Mukramin, Haiyan Wang, Zihao Wang, Latif Ullah Khan, Funing Zhang, Faisal Durrani, Fu-Gen Wu, and Fengming Lin*. Biomass-based carbon dots for Fe3+ and adenosine triphosphate detection in mitochondria.ACS Applied Nano Materials, 2023, 6, 1, 76–85.

(5)      Samran Durrani, Zihuayuan Yang, Jie Zhang, Zihao Wang, Haiyan Wang, Faran Durrani, Fu-Gen Wu, Fengming Lin*.Nucleus-targeting pH-responsive carbon dots for fast nucleus pH detection. Talanta, 2023, 152:123855.

(6)      Zihuayuan Yang, Xin Hu, Funing Zhang, Samran Durrani, Jie Zhang, Ai-Ping Pang, Yichen Gao, Fu-Gen Wu, Fengming Lin*. Chitosan-modified fluorescent dye for simple, fast, and in-situ measurement of fungal cell growth in the presence of insoluble compounds. FEMS Microbiology Letters, 2022, 369,1,fnac118.

(7)      Haiyan Wang, Ai-Ping Pang, Wei Wang, Bingzhi Li, Chengcheng Li,Fu-Gen Wu, Fengming Lin*. Discovery of ER-localized sugar transporters for cellulase production with lac1 being essential. Biotechnology for Biofuels and Bioproducts, 2022, 15: 132. 

(8)      Jie Zhang, Funing Zhang, Xin Hu, Jing Yang, Haiyan Wang, Samran Durrani, Fu-Gen Wu, Fengming Lin*. Self-Assembly and Disassembly of Glycol Chitosan/Photosensitizer Nano-Micelles for Antibacterial Photodynamic Therapy. ACS Applied Polymer Materials, 2022.

(9)      Fengming Lin, Chenyang Jia, and Fu-Gen Wu*. Intracellular enzyme-instructed self-assembly of peptides (IEISAP) for biomedical applications. Molecules, 2022, 27, 6557.

(10)    Fengming Lin, Zihao Wang and Fu-Gen Wu*. Carbon dots for killing microorganisms: An update since 2019. Pharmaceuticals, 2022, 15, 1236.

(11)    Chengcheng Li, Ruihan Gu, Fengming Lin*, Huining Xiao*. Sorbicillinoids hyperproduction without affecting the cellulosic enzyme production in Trichoderma reesei JNTR5. Biotechnology for Biofuels, 2022, 15: 85.

(12)    Fengming Lin, Cheyang Jia, Fu-Gen Wu*,Carbon dots for intracellular sensing. Small Structures, 2022, 3, 2200033.

(13)    Ai-Ping Pang, Yongsheng Luo, Xin Hu, Funing Zhang, Haiyan Wang, Yichen Gao, Samran Durrani, Chengcheng Li, Xiaotong Shi, Fu-Gen Wu, Bing-Zhi Li, Zuhong Lu*, Fengming Lin*. Transmembrane transport process and endoplasmic reticulum function facilitate the role of gene cel1b in cellulase production of Trichoderma reesei. Microbial Cell Factories, 2022.

(14)    Yichen Gao, Ai-Ping Pang, Leyao Ma, Haiyan Wang, Samran Durrani, Bingzhi Li, Fu-Gen Wu, Fengming Lin*. Intron retention coupled with nonsense-mediated decay is involved in cellulase biosynthesis in cellulolytic fungi. Biotechnology for Biofuels, 2022.

(15)    Samran Durrani, Jie Zhang, Ai-Ping Pang, Yichen Gao, Tian-Yu Wang, Haiyan Wang, Fu-Gen Wu, Fengming Lin*. Carbon dots for multicolor cell imaging and ultra-sensitive detection of multiple ions in living cells: one stone for multiple birds. Environmental Research, 2022,212:1113260.

(16)    Samran Durrani, Jie Zhang, Zihuayuan Yang, Ai-Ping Pang, Jia Zeng, Sayed Mir Sayed, Adeel Khan, Yaqin Zhang, Fu-Gen Wu, Fengming Lin*. Plant-derived Ca, N, S-Doped carbon dots for fast universal cell imaging and intracellular Congo red detection. Analytica Chimica Acta, 2022, 339672.

(17)    Jie Zhang, Zihuayuan Yang, Yan-Hong Li, Samran Durrani, Ai-Ping Pang, Yichen Gao, Fu-Gen Wu, Fengming Lin*. Super stable chitosan-based nanoparticles for broad-spectrum antimicrobial photodynamic therapy.ACS Applied Polymer Materials, 2022, 4:425–434.

(18)    Ai-Ping Pang, Funing Zhang, Xin Hu, Yongsheng Luo, Haiyan Wang, Samran Durrani, Fu-Gen Wu, Bing-Zhi Li, Zhihua Zhou, Zuhong Lu*, Fengming Lin*. Glutamine involvement in nitrogen regulation of cellulase production in fungi. Biotechnology for Biofuels, 2021, 14:199.

(19)    Ai-Ping Pang, Haiyan Wang, Funing Zhang, Xin Hu, Fu-Gen Wu, Zhihua Zhou, Wei Wang, Zuhong Lu*, Fengming Lin*. High-dose rapamycin exerts a temporary impact on T. reesei RUT-C30 through gene trFKBP12. Biotechnology for Biofuels, 2021, 14:77. 

(20)    Ai-Ping Pang, Haiyan Wang, Yongsheng Luo, Zihuayuan Yang, Zhiyu Liu, Zhao Wang, Bingzhi Li, Song Yang, Zhihua Zhou, Xiaolin Lu, Fu-Gen Wu, Zuhong Lu*, Fengming Lin*. Dissecting cellular function and distribution of β-glucosidases in Trichoderma reesei. mBio, 2021, 12(3):e03671-20.

(21)    Fengming Lin, Qiu-Yi Duan, and Fu-Gen Wu*. Conjugated Polymer-Based Photothermal Therapy for Killing Microorganisms. ACS Applied Polymer Materials, 2020, 2, 4331−4344.

(22)    Zihuayuan Yang, Ying Qiao, Junying Li, Fu-Gen Wu, Fengming Lin*. Novel Water-Soluble Photosensitizer from Trichoderma reesei for photodynamic inactivation of gram-positive bacteria. Langmuir 2020, 36, 44, 13227–13235.

(23)    Liang Ma, Ai‑Ping Pang, Yongsheng Luo, Xiaolin Lu* and Fengming Lin*. Beneficial factors for biomineralization by ureolytic bacterium Sporosarcina pasteurii.Microbial Cell Factory, 2020, 19:12.

(24)    Chengcheng Li, Ai-Ping Pang, Hang Yang, Rongjin Lv, Zhihua Zhou, Fu-Gen Wu, Fengming Lin*. Tracking localization and secretion of cellulase spatiotemporally and directly in living Trichoderma reesei. Biotechnology for biofuels, 2019,12, 200.

(25)    Fengming Lin, Hao-Ran Jia, and Fu-Gen Wu. Glycol chitosan: A water-soluble polymer for cell imaging and drug delivery. Molecules 24.23 (2019): 4371.

(26)    Fengming Lin, Yan-Wen Bao, and Fu-Gen Wu. Carbon Dots for Sensing and Killing Microorganisms. C-Journal of Carbon Research, 2019, 5: 33.

(27)    Chengcheng Li, Fengming Lin*, Wei Sun, Shaoxun Yuan, Zhihua Zhou, FuGen Wu and Zhan Chen. Constitutive hyperproduction of sorbicillinoids in Trichoderma reesei ZC121. Biotechnology for Biofuels, 2018, 11:291.

(28)    Fengming Lin, Yan-Wen Bao and Fu-Gen Wu. Improving the Phototherapeutic Efficiencies of Molecular and Nanoscale Materials by Targeting Mitochondria. Molecules, 2018, 23, 3016.

(29)    Fengming Lin*, Chengcheng Li, and Zhan Chen. Exopolysaccharide-Derived Carbon Dots for Microbial Viability Assessment. Frontiers in Microbiology. 2018, 9. 2697.

(30)    Chengcheng Li, Fengming Lin*, Wei Sun, Fu-Gen Wu, Hang Yang, Roujing Lv, Ya-Xuan Zhu, Hao-Ran Jia, Chu Wang, Ge Gao, and Zhan Chen. Self-assembled rose bengal-exopolysaccharide nanoparticles for improved photodynamic inactivation of bacteria by enhancing singlet oxygen generation directly in the solution. ACS Applied Materials & Interfaces, 2018, 10(19), 16715-16722.

(31)    Fengming Lin*, Chengcheng Li, Zhan Chen. Bacteria-derived carbon dots inhibit biofilm formation of Escherichia coli without affecting cell growth. 2018, Frontiers in Microbiology, 2018, 9, 259.

(32)    Chengcheng Li,Fengming Lin*, Le Zhou, Lei Qin, Bingzhi Li, Zhihua Zhou, Mingjie Jin, Zhan Chen. Cellulase hyper-production by Trichoderma reesei mutant SEU-7 on lactose. Biotechnology for Biofuels, 2017, 10, 228.

(33)    Fengming Lin*, Chengcheng Li, Li Dong, Degang Fu, and Zhan Chen*. Imaging biofilm-encased microorganisms using carbon dots derived from L. plantarum. Nanoscale, 2017,9, 9056-9064.

(34)    Chengcheng Li, Le Zhou, Hang Yang, Roujing Lv, Peilong Tian, Xu Li, Yaqin Zhang, Zhan Chen*, Fengming Lin*. Self-assembled Exopolysaccharide Nanoparticles for Bioremediation and Green Synthesis of Noble Metal Nanoparticles. ACS Applied Materials & Interfaces, 2017,9, 22808−22818.

(35)    Chengcheng Li, Fengming Lin*, Yizhen Li, Wei Wei, Hongyin Wang, Lei Qin, Zhihua Zhou, Bingzhi Li, Fugen Wu, Zhan Chen, A beta-glucosidase hyper-production Trichoderma reesei mutant reveals a potential role of cel3D in cellulose production. Microbial Cell Factories, 2016 15(1): 151.

(36)    Fengming Lin, Kyle L. Fergusion, David R. Boyer, Xiaoxia Nina Lin, E. Neil G. Marsh. Isofunctional enzymes PAD1 and UbiX catalyze formation of a novel cofactor required by Ferulic Acid Decarboxylase and 4-Hydroxy-3-polyprenylbenzoic Acid Decarboxylase. ACS Chemical Biology, 2015, 10, 1137-1144.

(37)    Fengming Lin, E. Neil G. Marsh, Xiaoxia Nina Lin. Recent progress in hydrocarbon biofuel synthesis: pathways and enzymes. Chinese Chemical Letters, 2015, 26, 431-434.

(38)    Fengming Lin, Yu Chen, Robert Levine, Kilho Lee, Yingjin Yuan, Xiaoxia Nina Lin. Improving fatty acid availability for bio-hydrocarbon production in Escherichia coli by metabolic engineering. PLoS One, 2013, 8(10): e78595.

(39)    Fengming Lin, Debasis Das, Xiaoxia Nina Lin, E. Neil G. Marsh. Aldehyde-forming fatty acyl-CoA reductase from cyanobacteria: expression, purification and characterization of the recombinant enzyme.FEBS Journal, 2013, 280:4773-4781. 

(40)    Fengming Lin, Ying Tan, Ying-jin Yuan. Temperal quantitative proteomics of Saccharomyces cerevisiae in response to a nonlethal concentration of furfural. Proteomics, 2009, 9:5471-5483.

(41)    Fengming Lin, Bin Qiao, Ying-jin Yuan. Comparative proteomic analysis of tolerance and adaptation of ethanologenic Saccharomyces cerevisiae to furfural, a lignocellulosic inhibitory compound. Applied and Environmental Microbiology, 2009, 75(1):3765-3776.