Title: Modeling of Degenerative Intervertebral Disc Disease and in-silico Clinical Trials for Disc Repair


Time:2018.4.10 AM10:00

PLCAE: State key laboratory of bioelectronics



     The intervertebral disc (IVD) is the largest avascular structure in the human body and its main function is to support load and to provide the flexibility for the spine system.Degenerative disc disease (DDD) is related to low back pain which affects more than 600 million people worldwide. Understanding degenerative processes in human IVD is challenging, due mainly to the complicated interactions among biological, chemical, electrical, and mechanical signals.

     In this talk, a 3D computer model for IVDs will be presented. Simulations of IVD degeneration and long-term efficacy of cellular therapies for disc repair will be discussed.



Weiyong Gu, PhD, University of Miami, College of Engineering, Department of Mechanical and Aerospace Engineering, Professor of Biomedical Engineering





Dr. Gu received his PhD in Mechanical Engineering at Columbia University in 1994.After completing his postdoctoral training and serving as an Associate Research Scientist in the Orthopaedic Research Lab, Department of Orthopaedic Surgery at Columbia University, Dr. Gu joined the University of Miami College of Engineering faculty in the Department of Biomedical Engineering in 1998. Since 2011, Dr. Gu has been a professor in the Department of Mechanical and Aerospace Engineering at the same university.


Over the past 25 years, Dr. Gu has been continuously developing new theory and constitutive relations for transport and mechanical properties, new computational models, and innovative experimental techniques for cartilaginous tissues.He has published more than 170 papers and abstracts in the area of tissue mechanics, transport phenomena, computational biomechanics, bioreactor technology, disc cell metabolism, and IVD degeneration and repair.