Organ on a Chip

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Colloidal Crystals

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Controlled Microstructural Architectures

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About ZhongZe Gu

Zhongze Gu is currently the professor and the dean of School of Biological Science and Medical Engineering of Southeast University, the director of JITRI Institute of Biomaterials and Biomedical Devices.

Zhongze Gu is currently the professor and the dean of the School of Biological Science and Medical Engineering of Southeast University, and the director of JITRI Institute of Biomaterials and Biomedical Devices. He is an elected fellow of the American Institute for Medical and Biological Engineering (2020), the Royal Society of Chemistry (2020).

He graduated from Southeast University (China) in 1989 and got his M.S. degree in 1992 there. He received his Ph.D. degree in 1998 from the University of Tokyo. He started his academic career in 1998 in KAST as a researcher. From 2003, he has been a Cheung Kong Scholars Professor at Southeast University. His research interests include bio-inspired intelligent materials, colloidal crystals, and organ-on-a-chip.

2017
The Distinguished Lectureship Award, The Chemical Society of Japan
2015
The second class prize of Science and technology progress award of the Ministry of Education (Biosafety research and clinical application of a novel bioartificial liver with xenogeneic cells)
2014
Gold medal of 42th Geneva International Invention Exhibition (Construction of biochip based on photonic bead array)
2012
The first class prize of science and technology of Jiangsu province (Development and clinical application of a novel bio-artificial liver system)
2011
The first class prize of the natural science award of the Ministry of Education (Methods for biomedical assay based on nanomaterials)

Projects

News

2017.7.12-14, Workshop on Microfluidic Chip and Tissue Engineering, Nanjing, Jiangsu
2017.6.9-11, Workshop on Microfluidic Chip and Tissue Engineering, Nanjing, Jiangsu
2016.9.22-25, The 22nd China-Japan Bilateral Symposium on Intelligent Electrophotonic Materials and Molecular Electronics (SIEMME’22) 2016, Chairman, Suzhou, China
2014.11.01-03, International Symposium on Integrated Molecular/Materials Science and Engineering, Nanjing
2010.9.19 –22, The 5th International Symposium on Integrated Molecular/Materials Engineering (ISIMME’ 5)

Photonic Crystals

Natural structural color materials, especially those that can undergo reversible changes, are attracting increasing interest in a wide variety of research fields. Inspired by the natural creatures, many elaborately nanostructured photonic materials with variable structural colors were developed. These materials have found important applications in switches, display devices, sensors, and so on.

In our group, we focus on the research studies of Self-assembled Photonic Crystals (PhCs) and their Applications in Biomedical Analysis.

(1) Self-assembled Colloidal Crystals;

(2) Bio-inspired Variable Structural Color Materials;

(3) Encoding Suspension Arrays based on Colloidal Crystals Beads;

(4) Label-Free Bioassays based on PhCs Microcarriers;

Selected Publications:

(1)Gu, Z. Z.; Fujishima, A.; Sato, O. Patterning of a Colloidal Crystal Film on a Modified Hydrophilic and Hydrophobic Surface. Angew. Chem. Int. Ed. 2002, 41 (12), 2067–2070.

(2)Gu, Z. Z.; Uetsuka, H.; Takahashi, K.; Nakajima, R.; Onishi, H.; Fujishima, A.; Sato, O. Structural Color and the Lotus Effect. Angew. Chem. Int. Ed. 2003, 42 (8), 894–897.

(3)Zhao, Y.; Zhao, X.; Hu, J.; Xu, M.; Zhao, W.; Sun, L.; Zhu, C.; Xu, H.; Gu, Z. Z. Encoded Porous Beads for Label-Free Multiplex Detection of Tumor Markers. Adv. Mater.2009, 21 (5), 569–572.

(4)Zhao, Y.; Xie, Z.; Gu, H.; Zhu, C.; Gu, Z. Z. Bio-Inspired Variable Structural Color Materials. Chem. Soc. Rev. 2012, 41 (8), 3297–3317.

(5)Liao, J.; Zhu, C.; Gao, B.; Zhao, Z.; Liu, X.; Tian, L.; Zeng, Y.; Zhou, X.; Xie, Z.; Gu, Z. Z. Multiresponsive Elastic Colloidal Crystals for Reversible Structural Color Patterns. Adv. Funct. Mater. 2019, 29 (39), 1902954.

Laser 3D Printing

Innovation in the field of nanotechnology has promoted the development of artificially designed microstructures and nanostructures with controlled properties which can be defineded controlled microstructural architectures (CMAs).One of the challenges in this field is to realize the architectures with growing structural complexity and multilevel hierarchy.

In our group, we focus on the research studies of Controlled Microstructural Architectures based on Laser 3D printing.

(1) Multi-scale Laser 3D printing based on Editable Focal Spot;

(2) Vertex Cloud Confinement Algorithm for Printing Trajectories;

(3) Materials with Controlled Mechanics;

(4) Materials with Controlled Wettability;

Selected Publications:

(1)Liu, X.; Gu, H.; Wang, M.; Du, X.; Gao, B.; Elbaz, A.; Sun, L.; Liao, J.; Xiao, P.; Gu, Z. Z. 3D Printing of Bioinspired Liquid Superrepellent Structures. Adv. Mater. 2018, 30 (22), 1800103.

(2)Ding, H.; Zhang, Q.; Gu, H.; Liu, X.; Sun, L.; Gu, M.; Gu, Z. Z. Controlled Microstructural Architectures Based on Smart Fabrication Strategies. Adv. Funct. Mater.2020, 30 (2), 1901760.

(3)Sun, L.; Gu, H.; Liu, X.; Ni, H.; Li, Q.; Zeng, Y.; Chang, N.; Zhang, D.; Chen, H.; Li, Z.; Zhao, X.; Gu, Z. Z. 3D-Printed Cellular Tips for Tuning Fork Atomic Force Microscopy in Shear Mode. Nat. Commun.2020, 11 (1), 5732.

(4)Liu, X.; Wei, M.; Wang, Q.; Tian, Y.; Han, J.; Gu, H.; Ding, H.; Chen, Q.; Zhou, K.; Gu, Z. Z. Capillary-Force-Driven Self-Assembly of 4D-Printed Microstructures. Adv. Mater. 2021, 33 (22), 2100332.

(5)Zhang, J.; Ding, H.; Liu, X.; Gu, H.; Wei, M.; Li, X.; Liu, S.; Li, S.; Du, X.; Gu, Z. Z. Facile Surface Functionalization Strategy for Two-Photon Lithography Microstructures. Small2021, 17 (34), 2101048.

Organ-on-a-Chip

Organs-on-a-chip systems are physiological platforms that reconstitute the critical features of human organs and the interactions between different tissues. They bring benefits to a diversity of applications, including drug discovery, toxicity testing, and disease modeling.

In our group, we focus on the research studies of the fabrication, setup, and application of Organ-on-a-Chip.

(1) Chip design and fabrication;

(2) Materials for Organ-on-a-Chip;

(3) High Content AI-based Screening System

(4) Organ-on-a-Chip Database (Website: http://117.73.8.164:8083/)

Selected Publications:

(1)Feng, Z. Q.; Chu, X.; Huang, N. P.; Wang, T.; Wang, Y.; Shi, X.; Ding, Y.; Gu, Z. Z. The Effect of Nanofibrous Galactosylated Chitosan Scaffolds on the Formation of Rat Primary Hepatocyte Aggregates and the Maintenance of Liver Function. Biomaterials2009, 30 (14), 2753–2763.

(2)Liu, W.; Shang, L.; Zheng, F.; Lu, J.; Qian, J.; Zhao, Y.; Gu, Z. Photonic Crystal Encoded Microcarriers for Biomaterial Evaluation. Small2014, 10 (1), 88–93.

(3)Zheng, F.; Fu, F.; Cheng, Y.; Wang, C.; Zhao, Y.; Gu, Z. Z. Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems. Small2016, 12 (17), 2253–2282.

(4)Chen, Z.; Ma, N.; Sun, X.; Li, Q.; Zeng, Y.; Chen, F.; Sun, S.; Xu, J.; Zhang, J.; Ye, H.; Ge, J.; Zhang, Z.; Cui, X.; Leong, K.; Chen, Y.; Gu, Z. Z. Automated Evaluation of Tumor Spheroid Behavior in 3D Culture Using Deep Learning-Based Recognition. Biomaterials2021, 272, 120770.

(5)Zhang, J.; Chen, Z.; Zhang, Y.; Wang, X.; Ouyang, J.; Zhu, J.; Yan, Y.; Sun, X.; Wang, F.; Li, X.; Ye, H.; Sun, S.; Yu, Q.; Sun, J.; Ge, J.; Li, Q.; Han, Q.; Pu, Y.; Gu, Z. Construction of a High Fidelity Epidermis-on-a-Chip for Scalable in Vitro Irritation Evaluation. Lab Chip2021. doi.org/10.1039/D1LC00099C.

Hybrid Artificial Intelligence

Despite its expertise in human-like automation, artificial intelligence (AI) is still not good at common sense, emotions, adaptabilities, and so on. To narrow the gap between machine and human, the hybrid of human brain and AI chips is drawing researchers' attention. It brings together the best aspects of neural networks and classical AI.

In our group, we focus on the cultivation and functionalization of human brain organoids, and the research and development of related sensors, modules, and equipment.

(1)Long-term human neural cells culture on microelectrode arrays (MEAs);

(2)Light sheet microscope for quasi-real time observation of nervous activities;

(3)Formation and reconfiguration of neural networks using multiple stimuli (optical, electrical, chemical, mechanical, etc);

(4)Automatic environment responsive brain organoids.

ZHONGZE GU

关于顾忠泽

About ZhongZe Gu

Zhongze Gu is currently the professor and the dean of the School of Biological Science and Medical Engineering of Southeast University, and the director of JITRI Institute of Biomaterials and Biomedical Devices. He is an elected fellow of the American Institute for Medical and Biological Engineering (2020), the Royal Society of Chemistry (2020).

He graduated from Southeast University (China) in 1989 and got his M.S. degree in 1992 there. He received his Ph.D. degree in 1998 from the University of Tokyo. He started his academic career in 1998 in KAST as a researcher. From 2003, he has been a Cheung Kong Scholars Professor at Southeast University. His research interests include bio-inspired intelligent materials, colloidal crystals, and organ-on-a-chip.

Education

1995.04 - 1998.03
The University of Tokyo, Applied Chemistry, Doctor degree.

1994.10 - 1995.03
The University of Tokyo, Applied chemistry, Research students.

1992.09 - 1994.09
Southeast University, Biological Science and Medical Engineering, Doctor graduate student.

1989.09 - 1992.03
Southeast University, Biological Science and Medical Engineering, Master degree.

1985.09 - 1989.07
Southeast University, Biological Science and Medical Engineering, bachelor degree.

Experience

2018
Vice President of Jiangsu Research Hospital Association

2017
Editorial Board Members of Bio-Design and Manufacturing

2015
Council Member of Chinese Society of Biomedical Engineering

2014
Director of Institute of Biomaterials and Devices, Jiangsu Industrial Technology Research Institute

2014
Member of the Evaluation Committee of Biomedical Engineering, Academic Degrees Committee of the State Council

2014
Dean of School of Biological Science and Medical Engineering, Southeast University, China

2012
Council Member of Chinese Society for Biomaterials

2012
Editorial Board Members of Chinese Chemical Letters

2008 - 2016
Director of State Key Laboratory of Bioelectronics, China

2002
Professor of School of Biological Science and Medical Engineering, Southeast University, China

1998 - 2003
Research Scientist of Kanagawa Academy of Science and Technology, Japan

International Conference Chair

2017.07.12 - 14
Workshop on Microfluidic Chip and Tissue Engineering, Nanjing, Jiangsu

2017.06.09 - 11
Workshop on Microfluidic Chip and Tissue Engineering, Nanjing, Jiangsu

2016.09.22 - 25
The 22nd China-Japan Bilateral Symposium on Intelligent Electrophotonic Materials and Molecular Electronics (SIEMME’22) 2016, Chairman, Suzhou, China

2014.11.01 - 03
International Symposium on Integrated Molecular/Materials Science and Engineering, Nanjing

2013.07.05 - 07
The International Conference on Self-assembled Functional Materials, Nanjing

2010.09.19 – 22
The 5th International Symposium on Integrated Molecular/Materials Engineering (ISIMME’ 5)

2009.08.21 - 26
The China-Germany Bilateral Symposium on Bioelectronics and Biomaterials (IWBB2009), Nanjing

2008.11
Japan-China Bilateral Workshop on Target Materials & Laser Plasma 2008, Chairman, Osaka, Japan

2008.09
The 15th China-Japan Bilateral Symposium on Intelligent Electrophotonic Materials and Molecular Electronics (SIEMME’ 15), Chairman, Dalian, Liaoning

2008.06
International Workshop on Bioelectronics and Biomaterials (IWBB2008), Chairman, Nanjing, Jiangsu

2007.11
The 14th China-Japan Bilateral Symposium on Intelligent Electrophotonic Materials and Molecular Electronics (SIEMME’ 14), Chairman, Nanjing, Jiangsu

2007.07
China-Japan Bilateral Workshop on Target Materials 2007，Chairman, Huangshan, Anhui

2004.11
The 11th China-Japan Bilateral Symposium on Intelligent Electrophotonic Materials and Molecular Electronics (SIEMME’ 11)，Chairman, Yunnan Kunming

Awards

2015
The second class prize of Science and technology progress award of the Ministry of Education (Biosafety research and clinical application of a novel bioartificial liver with xenogeneic cells)

2014
Gold medal of 42th Geneva International Invention Exhibition (Construction of biochip based on photonic bead array)

2012
The first class prize of science and technology of Jiangsu province (Development and clinical application of a novel bio-artificial liver system)

2011
The first class prize of the natural science award of the Ministry of Education (Methods for biomedical assay based on nanomaterials)

2010
The second class prize of the Chinese medical science and Technology Award (Bioreactor of mass produce of cells for the application of bio-artificial liver)

2007
The Distinguished Lectureship Award, The Chemical Society of Japan

News

CONTACT
INFORMATION

How to join the lab

Postdoctoral fellow candidates with a passion for creating the future are encouraged to write to Prof. Gu at gu@seu.edu.cn, including a description of your experiences, interests, and current and future goals. I also suggest that you apply for a Postdoctoral Fellowship.

SEU “Zhishan Postdoctor”: https://rsc.seu.edu.cn/2021/0504/c3599a370113/page.htm

Graduate students interested in doing research should write to Prof. Gu at gu@seu.edu.cn, including a CV and a description of your research interests. The students from Biomedical Engineering, Electronics, Computer Science, Physics, Chemistry, Medicine are welcome.

Undergraduates from almost any SEU department can do research in our lab. You should write to Prof. Gu at gu@seu.edu.cn, including a description of your short-term and long-term research interests (SRTP or summer schools).

招聘信息：

博士后：有志于来我们实验室开展博士后研究工作的研究人员，请通过邮件与顾老师（gu@seu.edu.cn）联系，请准备一份个人简历和未来研究计划。同时，我们建议您申请国家和学校的博士后资助项目。

中国博士后科学基金会“博新计划”：http://jj.chinapostdoctor.org.cn/website/index.html

东南大学“至善博士后”计划：https://rsc.seu.edu.cn/2021/0504/c3599a370113/page.htm

研究生：有志于来我们实验室攻读博士或硕士学位的研究生，请通过邮件与顾老师（gu@seu.edu.cn）联系，请准备一份个人简历和未来研究计划。我们欢迎生物医学工程、电子、计算机、物理、化学、医学等学科背景的学生。

本科生：欢迎东南大学所有在校本科生来我们实验室参观学习。可以通过邮件与顾老师（gu@seu.edu.cn）联系，请简要介绍个人研究兴趣和计划（SRTP或者暑期学校均可以）。

每周六上午九点，顾忠泽团队会在四牌楼校区逸夫科技馆三楼会议室举行Seminar。感兴趣的同学可申请参会。
Email
gu@seu.edu.cn
Tel/Fax
025-83795635
Address
State Key Laboratory of Bioelectronics, Southeast University,
2nd Sipailou, Nanjing, China
中国南京市，四牌楼2号东南大学生物电子学国家重点实验室

Email

Tel/Fax

Address

Organ on a Chip

Colloidal Crystals

Controlled Microstructural Architectures

About ZhongZe Gu

Projects

Photonic Crystals

Laser 3D Printing

Organ-on-a-Chip

Hybrid Artificial Intelligence

News

Research Direction

Photonic Crystals

Laser 3D Printing

Organ-on-a-Chip

Hybrid Artificial Intelligence

ZHONGZE GU

关于顾忠泽

About ZhongZe Gu

Education

Experience

International Conference Chair

Awards

News

CONTACT INFORMATION

How to join the lab

招聘信息：

Email

Tel/Fax

Address

CONTACT
INFORMATION