Organs-on-a-chip systems are physiological platforms that reconstitute the critical features of human organs and the interactions between different tissues. They bring benefits to a diversity of applications, including drug discovery, toxicity testing, and disease modeling.
In our group, we focus on the research studies of the fabrication, setup, and application of Organ-on-a-Chip.
(1) Chip design and fabrication;
(2) Materials for Organ-on-a-Chip;
(3) High Content AI-based Screening System
(4) Organ-on-a-Chip Database (Website: http://117.73.8.164:8083/)
Selected Publications:
(1)Feng, Z. Q.; Chu, X.; Huang, N. P.; Wang, T.; Wang, Y.; Shi, X.; Ding, Y.; Gu, Z. Z. The Effect of Nanofibrous Galactosylated Chitosan Scaffolds on the Formation of Rat Primary Hepatocyte Aggregates and the Maintenance of Liver Function. Biomaterials2009, 30 (14), 2753–2763.
(2)Liu, W.; Shang, L.; Zheng, F.; Lu, J.; Qian, J.; Zhao, Y.; Gu, Z. Photonic Crystal Encoded Microcarriers for Biomaterial Evaluation. Small2014, 10 (1), 88–93.
(3)Zheng, F.; Fu, F.; Cheng, Y.; Wang, C.; Zhao, Y.; Gu, Z. Z. Organ-on-a-Chip Systems: Microengineering to Biomimic Living Systems. Small2016, 12 (17), 2253–2282.
(4)Chen, Z.; Ma, N.; Sun, X.; Li, Q.; Zeng, Y.; Chen, F.; Sun, S.; Xu, J.; Zhang, J.; Ye, H.; Ge, J.; Zhang, Z.; Cui, X.; Leong, K.; Chen, Y.; Gu, Z. Z. Automated Evaluation of Tumor Spheroid Behavior in 3D Culture Using Deep Learning-Based Recognition. Biomaterials2021, 272, 120770.
(5)Zhang, J.; Chen, Z.; Zhang, Y.; Wang, X.; Ouyang, J.; Zhu, J.; Yan, Y.; Sun, X.; Wang, F.; Li, X.; Ye, H.; Sun, S.; Yu, Q.; Sun, J.; Ge, J.; Li, Q.; Han, Q.; Pu, Y.; Gu, Z. Construction of a High Fidelity Epidermis-on-a-Chip for Scalable in Vitro Irritation Evaluation. Lab Chip2021. doi.org/10.1039/D1LC00099C.