Ji Min

发布者:孙翌发布时间:2014-12-05浏览次数:1162

Name

Ji Min

Professional titles

Professor

Doctoral supervisor OR Master's supervisor

Doctoral supervisor

Major

Nano medicine, Medicinal Chemistry

Academic expertise and research direction

1.Design, synthesis and application of novel pharmaceutical nano-material

2.Anti-tumor activity of multi-targets kinase inhibitors

3.Design and synthesis of central nerves system (CNS) drugs

4.Research of Drug delivery system

Current research and other projects

uJuly, 2011 – July, 2014

“Technology development and industrialization of enzyme catalyzed synthesis of high quality atorvastatin calcium and its intermediates”, Major Achievements Transfer Projects of Jiangsu province (BA2011130), the team leader.

uJuly, 2011 – July, 2014

“Continuous chromatographic separation technique for preparation of high purity Netilmicin”, Major Achievements Transfer Projects of Jiangsu province (BA2011035), the team leader.


uJuly, 2012 – July, 2014

“Green technology and industrialization of atorvastatin calcium preparation”, The prospective project of Jiangsu Province (BY2012203), the team leader.


uJuly, 2009 – July, 2012

“Multiple targets kinase inhibitors Segitinib for antitumor preclinical studies”, Social Development---Technology Supporting Program of Jiangsu province (BE2009639), the team leader.

Books and papers

Books:

1.Combinatory ChemistryChemical series of books in the 21st century  Chemical Industry press 2004.6. Jimin  Write

2.《Medicinal Chemistry》(Ordinary higher education 15 teaching materials of national-level planning Higher Education Press 2004.11. Jimin join writing

3.《Medicinal ChemistryThe guide for entrance of National operation pharmacist's qualifying examination Chinese Pharmaceutical Scientific and technological publishing house 1997,2001 Jimin join writing

Papers:


1. Zhang, S. G.; Feng, C. L.; Cai, J.; Chen, J. Q.; Hu, H. Y.; Ji, M. Solvent free synthesis of 2-acylpyrroles and its derivatives catalysed by reuseable zinc oxide. Journal of Chemical Research 2013, 480-482.

2. Zheng, Y. G.; Zheng, M.; Ling, X.; Liu, Y.; Xue, Y. S.; An, L.; Gu, N.; Ji, M. Design, synthesis, quantum chemical studies and biological activity evaluation of pyrazole-benzimidazole derivatives as potent Aurora A/B kinase inhibitors (vol 23, pg 3523, 2013). Bioorganic & Medicinal Chemistry Letters 2013, 23, 4471-4471.

3. Feng, C. L.; Zhang, S. G.; Chen, J. Q.; Cai, J.; Ji, M. First total synthesis of isoquinolinone alkaloid marinamide and its methyl ester. Chinese Chemical Letters 2013, 24, 767-769.

4. Zhang, S. G.; Huang, S.; Feng, C. L.; Cai, J.; Chen, J. Q.; Ji, M. Novel preparation of tiaprofenic acid. Journal of Chemical Research 2013, 406-408.

5. Zheng, M.; Zheng, Y. G.; Xie, L.; Chang, W. W.; Gu, N.; Ji, M. Orally Active Aurora A/B Kinase Inhibitor, AM-005, Suppresses the Growth of Human Colon Carcinoma Cells. Drug Development Research 2013,  74, 272-281.

6. Zheng, Y. G.; Zheng, M.; Liu, Y.; Xue, Y. S.; Zhang, L.; An, L.; Liu, L.; Ji, M. Design, Synthesis, and In vitro Antitumor Evaluation of Novel Phenylaminopyrimidine Derivatives. Medicinal Chemistry 2013, 9, 340-350.

7. Cai, J.; Sun, M.; Wu, X. Q.; Chen, J. Q.; Wang, P.; Zong, X.; Ji, M. Design and synthesis of novel 4-benzothiazole amino quinazolines Dasatinib derivatives as potential anti-tumor agents. European Journal Of Medicinal Chemistry 2013, 63, 702-712.

8. Zhang, S. G.; Feng, C. L.; Cai, J.; Chen, J. Q.; Ji, M. Total synthesis of a novel isoquinolinone alkaloid marinamide and its methyl ester. Journal of Chemical Research 2013, 291-293.

9. Zheng, M.; Zheng, Y. G.; Xue, Y. S.; Liu, Y.; An, L.; Zhang, L.; Ji, M.; Xue, B.; Wu, X.; Gong, X. D.; Gu, N.; Zhan, X. Synthesis and Quantum Chemical Studies of New 4-aminoquinazoline Derivatives as Aurora A/B Kinase Inhibitors. Chemical Biology & Drug Design 2013, 81, 399-407.

10. Wang, P.; Cai, J.; Yang, J. B.; Sun, C. L.; Li, L. S.; Ji, M. Solvent-Dependent Regioselective Oxidation of trans-Chalcones using Aqueous Hydrogen Peroxide. Journal Of The Brazilian Chemical Society 2013, 24, 518-522.

11. Wang, P.; Cai, J.; Yang, J. B.; Sun, C. L.; Li, L. S.; Hu, H. Y.; Ji, M. Zinc(II)-catalyzed oxidation of alcohols to carbonyl compounds with chloramine-T. Tetrahedron Letters 2013, 54, 533-535.

12. Duan, Y. B.; Ji, M.; Lu, X. H. Simultaneous high-performance liquid chromatographic determination of a rhein-diclofenac prodrug and its active compounds. Pharmazie 2013, 68, 12-14.

13. Wang, P.; Yang, J. B.; Cai, J.; Sun, C. L.; Li, L. S.; Ji, M. An efficient and facile synthesis of flavanones catalyzed by N-methylimidazole. Journal Of The Serbian Chemical Society 2013,  78, 917-920.

14. Cao, M.; Zhan, T. L.; Ji, M.; Zhan, X. Dimerization is necessary for MIM-mediated membrane deformation and endocytosis. Biochemical Journal 2012, 446, 469-475.

15. Cai, J.; Duan, Y. B.; Yu, J.; Chen, J. Q.; Chao, M.; Ji, M. Bone-targeting glycol and NSAIDS ester prodrugs of rhein: Synthesis, hydroxyapatite affinity, stability, anti-inflammatory, ulcerogenicity index and pharmacokinetics studies. European Journal Of Medicinal Chemistry 2012, 55, 409-419.

16. Hu, H. Y.; Liu, Y.; Zhong, H.; Zhu, Y. L.; Wang, C.; Ji, M. Heck-Type Cross-Dehydrogenative Coupling Reactions of Indolizines at the 3-Position with Electron-Deficient Alkenes through Palladium-Catalyzed C?H Activation. Chemistry-an Asian Journal 2012, 7, 884-888.

17. Cai, J.; Zhang, S. N.; Zheng, M.; Wu, X. Q.; Chen, J. Q.; Ji, M. Design, synthesis, and in vitro antiproliferative activity of novel Dasatinib derivatives. Bioorganic & Medicinal Chemistry Letters 2012,  22, 806-810.

18. Wu, X. Q.; Li, M. D.; Tang, W. H.; Zheng, Y. G.; Lian, J. Q.; Xu, L.; Ji, M. Design, Synthesis, and In vitro Antitumor Activity Evaluation of Novel 4-pyrrylamino Quinazoline Derivatives. Chemical Biology & Drug Design 2011, 78, 932-940.

19. Zheng, Y. G.; Sun, M.; Liu, Y.; Li, M. D.; Ji, M. Design, Synthesis of Novel Quinazolone Alkaloids Derivatives as Potential Antitumor Agents. Medicinal Chemistry 2011, 7, 295-300.

20. Chen, J. Q.; Sun, M.; Cai, J.; Cao, M.; Zhou, W.;  Ji, M. The Synthesis and Crystal Structure of (4 alpha,8 beta,13 beta,16 beta)-13-Methyl-16,18-diol-17-Norkaurane: A Simultaneous Reduction Product of Isosteviol. Journal Of Chemical Crystallography 2011, 41, 519-522.

21. Chen, J. Q.; Zha, X. M.; Sun, M.; Cai, J.; Zhou, W.; Ji, M. Synthesis and In Vivo Acute Antihyperglycemic Evaluation of Novel Isosteviol Derivatives. Letters in Drug Design & Discovery 2010,  7, 686-693.

22. Zheng, Y. G.; Wu, X. Q.; Xue, B.; Li, M. D.; Ji, M. Design, Synthesis, Docking and Antitumor Activity of Quinazolino [3, 4-a] thieno [3, 2-d] pyrimidin-8-one Derivatives. Chemical Biology & Drug Design 2010, 76, 285-290.

23. Wu, X. Q.; Li, M. D.; Qu, Y.; Tang, W. H.; Zheng, Y. G.; Lian, J. Q.; Ji, M.; Xu, L. Design and synthesis of novel Gefitinib analogues with improved anti-tumor activity. Bioorganic & Medicinal Chemistry 2010, 18, 3812-3822.

24. Sun, M.; Wu, X. Q.; Chen, J. Q.; Cai, J.; Cao, M.; Ji, M. Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives. European Journal Of Medicinal Chemistry 2010,  45, 2299-2306.

25. Sun, M.; Chen, J. Q.; Cai, J.; Cao, M.; Yin, S. Q.; Ji, M. Simultaneously Optimized Support Vector Regression Combined With Genetic Algorithm for QSAR Analysis of KDR/VEGFR-2 Inhibitors. Chemical Biology & Drug Design 2010, 75, 494-505.

26. Duan, Y. B.; Yu, J.; Liu, S.; Ji, M. Synthesis of Anthraquinone-Ibuprofen Prodrugs with Hydroxyapatite Affinity and Anti-Inflammatory Activity Characteristics. Medicinal Chemistry 2009,  5, 577-582.

27. Sun, M.; Zheng, Y. G.; Wei, H. T.; Chen, J. Q.; Ji, M. QSAR studies on 4-anilino-3-quinolinecarbonitriles as Src kinase inhibitors using robust PCA and both linear and nonlinear models. Journal Of Enzyme Inhibition And Medicinal Chemistry 2009, 24, 1109-1116.

28. Zheng, Y. G.; Wu, X. Q.; Sun, M.; Feng, L. H.; Li, M. D.; Ji, M. Design, Synthesis, Crystal Structure and Antitumor Activity of A New Ethyl 3-(quinazolin-4-ylamino)-1H-pyrrole-2-carboxylate Derivative. Letters in Drug Design & Discovery 2009, 6, 538-541.

29. Duan, Y. B.; Yu, J.; Liu, H. F.; Ji, M. Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics. Letters in Drug Design & Discovery 2009, 6, 393-396.

30. Sun, M.; Chen, J. Q.; Wei, H. T.; Yin, S. Q.; Yang, Y.; Ji, M. Quantitative Structure-Activity Relationship and Classification Analysis of Diaryl Ureas Against Vascular Endothelial Growth Factor Receptor-2 Kinase Using Linear and Non-Linear Models. Chemical Biology & Drug Design 2009, 73, 644-654.

31. Wei, H. T.; Sun, M.; Ji, M. A straightforward expeditious synthesis of 5-nitrobenzo[b]thiophene-2-carbaldehyde. Journal Of Chemical Research-s 2009, 359-360.

32. Zheng, Y. G.; Li, M. D.; Zhang, S. N.; Ji, M.  Novel preparation of gefitinib. Journal Of Chemical Research-s 2009, 388-390.

33. Sun, M.; Zheng, Y. G.; Wei, H. T.; Chen, J. Q.; Cai, J.; Ji, M. Enhanced Replacement Method-based Quantitative Structure - Activity Relationship Modeling and Support Vector Machine Classification of 4-Anilino-3-quinolinecarbonitriles as Src Kinase Inhibitors. Qsar & Combinatorial Science 2009, 28, 312-324.

34. Cai, J.; Zhou, W.; Chen, J. Q.; Sun, M.; Ji, M. Synthesis and Crystal Structure of Benzoyloxymethyl (4 alpha,8 beta,13 beta)-13-methyl-16-oxo-17-norkauran-18-carbonate Ester. Journal Of Chemical Crystallography 2009, 39, 108-111.

35. Liu, H. F.; Wu, X. Q.; Duan, Y. B.; Dou, R. B.; Sun, H. F.; Ji, M. An efficient one-pot synthesis of cyclovirobuxine A from buxozine C. Chemistry Of Natural Compounds 2008, 44, 829-830.

36. Shi, C. L.; Chen, H.; Li, Y.; Shi, D. Q.; Ji, M. A three-component synthesis of N-substituted quinoline-3-carbonitrile derivatives catalysed by L-proline. Journal Of Chemical Research-s 2008, 534-537.

37. Shi, C. L.; Shi, D. Q.; Kim, S. H.; Huang, Z. B.; Ji, S. J.; Ji, M. A novel and efficient one-pot synthesis of furo[3 ',4 ': 5,6]pyrido[2,3-c]pyrazole derivatives using organocatalysts. Tetrahedron 2008, 64, 2425-2432.

38. Liu, H. F.; Wu, X. Q.; Duan, Y. B.; Gu, B.; Ji, M. An efficient one-pot, two-step synthesis of cyclobuxophyllinine M from cyclovirobuxine D in aqueous media. Letters In Organic Chemistry 2008, 5, 140-141.

39. Yang, F.; Gu, A. Y.; Chen, Z. P.; Gu, N.; Ji, M.  Multiple emulsion microbubbles for ultrasound imaging. Materials Letters 2008,  62, 121-124.

40. Sun, M.; Wei, H. T.; Li, D.; Zheng, Y. G.; Cai, J.; Ji, M. Mild and efficient one-pot synthesis of 2-imidazolines from nitriles using sodium hydrosulfide as catalyst. Synthetic Communications 2008,  38, 3151-3158.

41. Shi, C. L.; Shi, D. Q.; Kim, S. H.; Huang, Z. B.; Ji, M. A novel and efficient synthesis of 3,3 '-benzylidenebis(4-hydroxy-6-methylpyridin-2(1H)-one) derivatives through a multi-component reaction catalyzed by L-proline. Australian Journal Of Chemistry 2008, 61, 547-551.

42. Wei, H.; Cai, J.; Sun, M.; Ji, M. Synthesis of substituted thieno[2,3-b]pyrroles. Heteroatom Chemistry 2007, 18, 236-238.

43. Liu, H. F.; Ji, M.; Cai, J. Short and efficient approach towards buxozine-C, an alkaloid from Buxus sempervirens. Archiv Der Pharmazie 2006, 339, 675-676.


Email

jimin@seu.edu.cn

Other explanation