Nongyue He



Nongyue He

Professional titles

Dr. Professor

Doctoral supervisor OR Master's supervisor

Both Doctoral supervisor and Master's supervisor


Chemistry; Biomedical Engineering; Biological Physics; Nanotechnology; Nanomaterials; Biosensors

Academic expertise and research direction

Academic expertise: Nanotechnology; Biosensors; Biomaterials; Controlled drug delivery; Biochips; Microarrays; Biomedical devices

Research Directions: Biomedical Engineering; Biological Physics; Nanotechnology; Biosensors

Current research and other projects

1.Natural Science Fund of China (61271056): Detection of Single Nucleic Acid Mutation with High Specificity, High Sensitivity and High Accuracy

2.National Key Program for Developing Basic Research of China (973) (2010CB933903): Nanotechnology of in vivo quantification and visualization of gastric cancer biomarkers

3.National Key Program for Developing Basic Research of China (973) (2014CB744501): Screening and checking of special molecular typing biomarkers for breast cancer in Chinese women

4.Chinese High-tech Project (863) (2012AA022703): Development of cost-effective devices for biomarker assay

5.National Key Special Science Program (2013ZX10004103-002): Multiplex PCR assay platform for infectious disease pathogens

Books and papers

1.Biochips Nanotechnology; Nongyue He, and Hari Singh Nalwa,ISBN: 978-1-58883-072-1, Copyright-2008 by American Scientific Publishers.

2.Nongyue He, Song Li, Hongna Liu, High-throughput SNP detection based on PCR amplification on magnetic nanoparticles using dual-color hybridization, the second edition of Single Nucleotide Polymorphisms in the Methods in Molecular Biology series, published by Humana Press (part of the Springer publishing group), (A.A. Komar (ed.), Single Nucleotide Polymorphisms, Methods in Molecular Biology  578, DOI 10.1007/978-1-60327-411-1 24, @ Humana Press, a part of Springer Science+Business Media, LLC 2009). ISSN: 1064-3745; 978-1-60327-401-4

3. Liming Zhang, Zunliang Wang,Zhuoxuan Lu, He shen,Jie Huang,Min Liu,Nongyue He,*and Zhijun Zhang*, PEGylated Reduced Graphene Oxide as a Superior ssRNA Delivery System, Journal of Materials Chemistry B, 2013,1(6): 749-755.

4. Chao Ma, Chuanyan Li, Fang Wang, Ningning Ma, Zhiyang Li, Zhijiang Xi, Xiaolong Li, Nongyue He*, Magnetic Nanoparticles-Based Extraction and Verification of Nucleic Acids from Different Sources,J. Biomed. Nanotechnol., 9, 703-709 (2013).

5. Song Li*, Hongna Liu, Yingying Jia, Xianbo Mou, Yan Deng, Lin Lin, Nongyue He, An Automatic High-throughput SNP Genotyping Approach Based on Universal Tagged Arrays and Magnetic Nanoparticles, J. Biomed. Nanotechnol.2013, 9, 689-698.

6. Hongrong Jiang, Xin Zeng, Zhijiang Xi, Ming Liu,Chuanyan Li,Zhiyang Li,Lian Jin,Zhifei Wang,Yan Deng, and Nongyue He*, Improvement on Controllable Fabrication of Streptavidin-Modified Three-Layer Core-Shell Fe3O4@SiO2@Au Magnetic Nanocomposites with Low Fluorescence Background, J. Biomed. Nanotechnol.9, 674-684 (2013).

7. Xuyuan Ji, Ting Wang, Lingling Guo, Jiangqiang Xiao, Zhiyong Li, Liming Zhang, Yan Deng, and Nongyue He*, Effection of Nano-ZnO on the Mechanical Property and Biocompatibility of Electrospun Poly(L-lactide) Acid/Nano-ZnO Mats,J. Biomed. Nanotechnol. 9, 417-423 (2013)

8. Yongjun Tang, Zhiyang Li, Nongyue He*,  Liming Zhang, Chao Ma, Xiaolong Li, Chuanyan Li, Zhifei Wang, Yan Deng, and Lei He, Preparation of Functionial Magnetic Nanoparticles Mediated with PEG 4000 and Application in Pseudomonas aeruginosa Rapid Detection, J. Biomed. Nanotechnol., 9, 312-317 (2013).

9. Nongyue He*, Fang Wang, Chao Ma, Chuanyan Li, Xin Zeng, Yan Deng, Liming Zhang, Zhiyang Li, Chemiluminescence Analysis for HBV-DNA Hybridization Detection with Magnetic Nanoparticles based DNA Extraction from Positive Whole Blood Samples, J. Biomed. Nanotechnol., 9, 267-273 (2013).

10. Bin Liu, Yingying Jia, Man Ma, Zhiyang Li, Hongna Liu, Song Li, Yan Deng, Liming Zhang, Zhuoxuan Lu, Wei Wang, and Nongyue He*, High Throughput SNP Detection System Based on Magnetic Nanoparticles Separation,J. Biomed. Nanotechnol. 9, 247-256 (2013).

11. Yongjun Tang, Jun Zou, Chao Ma, Zeeshan Ali, Zhiyang Li, Xiaolong Li, Ninging Ma, Xianbo Mou, Yan Deng, Liming Zhang, Kai Li, Guangming Lu, Haowen Yang, Nongyue He*, Highly Sensitive and Rapid Detection of Pseudomonas aeruginosa  Based on Magnetic Enrichment and Magnetic Separation, Theranostics, 2013, 3(2): 85-92.

12. Liming Zhang, Zhuoxuan Lu,Yingying Bai,Ting Wang, Zhifei Wang, Juan Chen,Yin Ding, Fei Yang, Zhongdang Xiao, Shenghong Ju, Junjie Zhu,Nongyue He*, PEGylated Denatured Bovine Serum Albumin Modified Water Soluble Inorganic Nanocrystals as Multifunctional Drug Delivery Platforms, J. Mater. Chem. B, 2013, 1 (9), 1289 - 1295.

13. Yan Deng*, Minghuan Wang, Li Jiang, Chao Ma, Zhijiang Xi,Xiaolong Li, Nongyue He*, A Comparison of Extracellular Excitatory Amino Acids Release Inhibition of Acute Lamotrigine and Topiramate Treatment in the Hippocampus of PTZ-kindled Epileptic Rats, J. Biomed. Nanotechnol. 9, 1123-1128 (2013).

14. Yan Deng*, Minghuan Wang, Wei Wang, Chao Ma, Nongyue He*, Comparison and Effects of Acute Lamotrigine Treatment on Extracellular Excitatory Amino Acids in the Hippocampus of PTZ-Kindled Epileptic and PTZ-Induced Status Epilepticus Rats. Neurochem Res. 2013, 38(3), 504-511.

15. Xuyuan Ji, Wenjing Yang, Ting Wang, Chun Mao, Lingling Guo, Jiangqiang Xiao, and Nongyue He*, Coaxially Electrospun Core/Shell Structured Poly(L-lactide) Acid/Chitosan Nanofibers for Potential Drug Carrier in Tissue Engineering, J. Biomed. Nanotechnol. 9, 1672-1678 (2013).

16. Ting Wang, Yan Hu, Michelle K. Leach, Long Zhang, Wenjing Yang, Li Jiang, Zhang-Qi Feng, Nongyue He*, Erythropoietin-loaded oligochitosan nanoparticles for treatment of periventricular leukomalacia, International Journal of Pharmaceutics, 422 (1-2), 462-471 (2012).

17. Fang Wang, Chao Ma, Xin Zeng, Chuanyan Li, Nongyue He*, Chemiluminescence Molecular Detection of Sequence-specific HBV-DNA Using Magnetic Nanoparticles, J. Biomed. Nanotechnol., 8, 786-790, 2012.

18. Bin Liu, Zhiyang Li, Hui Chen, Yan Deng, Nongyue He*, Sauli Elingarami, and Jin Huang, Development of a Total Temperature Micro-volume Blended Incubating and Hybridizing Apparatus for DNA Hybridization on Nanoparticles, J. Biomed. Nanotechnol., 2012, 8, 938-943.

19.Jing Shi, Demao Yao, Wei Liu, Na Wang, Hongjun Lv, Nongyue He, Bingyin Shi, Peng Hou* and Meiju Ji*, Frequent Gene Amplification Predicts Poor Prognosis in Gastric Cancer, Int. J. Mol. Sci., 13, 4714-4726 (2012).

20. Zhifei Wang*, Hongying Li, Shuang Zhen, Nongyue He, Preparation of carboxyl group-modified palladium nanoparticles in an aqueous solution and their conjugation with DNA, Nanoscale, 4  (11): 3536-3542 (2012).

21. Jing Shi, Demao Yao, Wei Liu, Na Wang, Hongjun Lv, Guanjun Zhang, Meiju Ji, Li Xu, Nongyue He, Bingyin Shi and Peng Hou*, Highly frequent PIK3CA amplification is associated with poor prognosis in gastric cancer, BMC Cancer 12:50, 2012.

22. Demao Yao, Jing Shi, Bingyin Shi, Na Wang, Wei Liu, Guanjun Zhang, Meiju Ji, Li Xu, Nongyue He, Peng Hou*, Quantitative assessment of gene methylation and their impact on clinical outcome in gastric cancer, Clinica Chimica Acta 413 (2012) 787–794.

23. Liming Zhang, Zhuoxuan Lu,* Xiaolong Li, Yan Deng, Fengqin Zhang, Chao Ma and  Nongyue He*, Methoxy poly(ethylene glycol) conjugated denatured bovine serum albumin micelles for effective delivery of camptothecin, Polym. Chem., 2012, 3, 1958-1961.

24. Zhuoxuan Lu*, Liming Zhang, Yan Deng, Song Li and Nongyue He*, Graphene Oxide for Rapid MicroRNAs detection, Nanoscale,2012, 4 (19), 5840 - 5842.

25. Song Li, Hongna Liu, Yingying Jia, Yan Deng, Liming Zhang, Zhuoxuan Lu, Nongyue He*, A Novel SNPs Detection Method Based on Gold Magnetic Nanoparticles Array and Single Base Extension, Theranostics, 2012, 2 (10): 967-975.

26. Chao Ma, Chuanyan Li, Nongyue He*, Fang Wang, Ningning Ma, Liming Zhang, Zhuoxuan Lu, Zeeshan Ali, Zhijiang Xi, Xiaolong Li, Gaofeng Liang, Hongna Liu, Yan Deng, Lijian Xu, Zhifei Wang, Preparation and Characterization of Monodisperse Core–shell Fe3O4@SiO2 Microspheres and Its Application for Magnetic Separation of Nucleic Acids from E.coli BL21, J. Biomed. Nanotechnol., 2012, 8, 1000-1005.


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