时间：4月10日上午10：00

地点：生物电子学国家重点实验室会议室  

Title: Modeling of Degenerative Intervertebral Disc Disease and in-silico Clinical Trials for Disc Repair

标题：退行性椎间盘疾病的建模及椎间盘修复的模拟临床试验

Abstract:

The intervertebral disc (IVD) is the largest avascular structure in the human body and its main function is to support load and to provide the flexibility for the spine system.Degenerative disc disease (DDD) is related to low back pain which affects more than 600 million people worldwide. Understanding degenerative processes in human IVD is challenging, due mainly to the complicated interactions among biological, chemical, electrical, and mechanical signals.

In this talk, a 3D computer model for IVDs will be presented. Simulations of IVD degeneration and long-term efficacy of cellular therapies for disc repair will be discussed.

摘要：

椎间盘（IVD）是人体内最大的无血管结构,它的主要功能是对脊柱系统进行负载支持并提供灵活性。椎间盘退变性疾病（DDD）与世界范围内6亿多人的腰痛有关。了解人类椎间盘退变的过程具有挑战性，主要是由于生物、化学、电气和机械信号的复杂的相互作用。

在这次讲座中，会介绍椎间盘的一个三维计算机模型。并且会讨论椎间盘退变和椎间盘细胞疗法修复的长期疗效的模拟。

Presenter:

Weiyong Gu, PhD, University of Miami, College of Engineering, Department of Mechanical and Aerospace Engineering, Professor of Biomedical Engineering

演讲人：

顾伟勇博士，迈阿密大学工学院机械与航天工程系教授和生物医学工程系教授

BIO:

Dr. Gu received his PhD in Mechanical Engineering at Columbia University in 1994.After completing his postdoctoral training and serving as an Associate Research Scientist in the Orthopaedic Research Lab, Department of Orthopaedic Surgery at Columbia University, Dr. Gu joined the University of Miami College of Engineering faculty in the Department of Biomedical Engineering in 1998. Since 2011, Dr. Gu has been a professor in the Department of Mechanical and Aerospace Engineering at the same university.

Over the past 25 years, Dr. Gu has been continuously developing new theory and constitutive relations for transport and mechanical properties, new computational models, and innovative experimental techniques for cartilaginous tissues.He has published more than 170 papers and abstracts in the area of tissue mechanics, transport phenomena, computational biomechanics, bioreactor technology, disc cell metabolism, and IVD degeneration and repair.

个人简历：

顾博士于1994获美国哥伦比亚大学机械工程博士学位。在哥伦比亚大学矫形外科系骨科研究室完成博士后训练, 并担任副研究员。顾博士于1998年加入了迈阿密大学工程学院生物医学工程系，自2011以来，顾博士在同一大学的机械和航天工程系任教授。

在过去的25年中，顾博士一直致力于发展与软组织有关的，传输及力学的本构关系，新的计算模型，和与软骨组织有关的创新实验技术。他已发表170多篇论文和摘要，涉及领域包括组织力学、传输现象，计算生物力学、生物反应器技术、椎间盘细胞的代谢，和椎间盘退变与修复。