吴富根

发布时间: 2013-05-05      访问次数: 14511

 

 

    吴富根,男,19839月出生,东南大学生物科学与医学工程学院,生物电子学国家重点实验室,博士,教授,博士生导师。江苏省“六大人才高峰”高层次人才(2015),江苏省“双创人才”(2016),江苏省优秀青年基金获得者(2017)。Chinese Chemical Letters青年编委。

教育工作情况:

2002-2006年,清华大学化学系,理学学士;

2006-2011年,清华大学化学系,理学博士,导师为尉志武教授;

2011-2013年,美国密歇根大学化学系,博士后,导师为Prof. Zhan Chen(陈战教授)。

20132月加入东南大学生物科学与医学工程学院,20134月被评为教授,201312月被评为博士生导师。

研究方向:

(1)细胞及亚细胞(细胞膜、线粒体、溶酶体、细胞核等)荧光成像及分析;

(2)生化检测、生物传感器;

(3)细胞表面工程及其在生物医学领域(抗癌、抗菌、成像、生物检测等)的应用;

(4)基于细胞自噬、癌细胞耐药性、肿瘤免疫疗法等思路寻找生物材料或生物分子的抗癌新应用。

研究成果:

以第一/通讯作者发表J. Am. Chem. Soc.Nano Lett.Adv. Funct. Mater.SmallJ. Control. ReleaseACS Appl. Mater. InterfacesNanoscaleChem. Commun.Anal. Chem.CarbonSCI论文近60篇(其中22篇影响因子大于7),多篇论文被选为期刊封面文章(包括J. Am. Chem. Soc.一次,Adv. Funct. Mater.一次,Nanoscale三次,Adv. Mater. Interfaces一次,J. Mater. Chem. B两次,ACS Biomater. Sci. Eng.一次),并被国内外多家网站(包括美国化学工程新闻网站C&ENMaterialsViewsChina,美国Pfizer公司网站、Global Medical Discovery等)、综述(包括Chem. Rev.Chem. Soc. Rev.等)和论文(包括Nature Nanotech.Perspective)等报道或评述。应邀撰写Springer图书章节一篇。已申请中国发明专利40余项,其中已授权14项。2011年获得清华大学优秀博士学位论文奖2014-2017年连续四年指导本科生获得江苏省优秀本科毕业设计(论文)一、二等奖(其中20142015年分别为东南大学第12名)。2015年入选东南大学“优秀青年教师科学研究资助计划”以及江苏省第十二批“六大人才高峰”高层次人才资助计划,2016年入选江苏省“双创人才”,2017年获江苏省优秀青年基金资助。主持国家自然科学基金2项(面上项目和青年基金各1项),省部级项目5项,东南大学校级项目3项,参与973863等重大科技项目多项。

  

5年代表性论文(2014-2018):

(1) Ya-Xuan Zhu#, Hao-Ran Jia#, Guang-Yu Pan, Nathan W. Ulrich, Zhan Chen*, and Fu-Gen Wu*. Development of a Light-Controlled Nanoplatform for Direct Nuclear Delivery of Molecular and Nanoscale Materials. J. Am. Chem. Soc. 2018, 140(11), 4062−4070. (Cover)

(2) Xiaokai Chen#, Xiaodong Zhang#, Liu-Yuan Xia, Hong-Yin Wang, Zhan Chen*, and Fu-Gen Wu*. One-Step Synthesis of Ultrasmall and Ultrabright Organosilica Nanodots with 100% Photoluminescence Quantum Yield: Long-Term Lysosome Imaging in Living, Fixed, and Permeabilized Cells. Nano Lett. 2018, 18(2), 1159−1167.

(3) Xiaodong Zhang, Xiaokai Chen, Yao-Wen Jiang, Ningning Ma, Liu-Yuan Xia, Xiaotong Cheng, Hao-Ran Jia, Peidang Liu, Ning Gu, Zhan Chen*, and Fu-Gen Wu*. Glutathione-Depleting Gold Nanoclusters for Enhanced Cancer Radiotherapy through Synergistic External and Internal Regulations. ACS Appl. Mater. Interfaces 2018, 10(13), 10601−10606.

(4) Xian-Wu Hua#, Yan-Wen Bao#, and Fu-Gen Wu.* Fluorescent Carbon Quantum Dots with Intrinsic Nucleolus-Targeting Capability for Nucleolus Imaging and Enhanced Cytosolic and Nuclear Drug Delivery. ACS Appl. Mater. Interfaces 2018, 10(13), 10664−10677.

(5) Yan-Wen Bao, Xian-Wu Hua, Yan-Hong Li, Hao-Ran Jia, and Fu-Gen Wu*. Hyperthemia-Promoted Cytosolic and Nuclear Delivery of Copper/Carbon Quantum Dot-Crosslinked Nanosheets: Multimodal Imaging-Guided Photothermal Cancer Therapy. ACS Appl. Mater. Interfaces 2018, 10(2), 1544−1555.

(6) Guang-Yu Pan, Hao-Ran Jia, Ya-Xuan Zhu, and Fu-Gen Wu*. Turning double hydrophilic into amphiphilic: IR825-conjugated polymeric nanomicelles for near-infrared fluorescence imaging-guided photothermal cancer therapy. Nanoscale 2018, 10, 2115−2127.

(7) Ge Gao#, Yao-Wen Jiang#, Hao-Ran Jia, Jingjing Yang, Fu-Gen Wu*. On-off-on fluorescent nanosensor for Fe3+ detection and cancer/normal cell differentiation via silicon-doped carbon quantum dots. Carbon 2018, 134, 232−243.

(8) Hai-Yuan Sun,# Geng Deng,# Yao-Wen Jiang, Yu Zhou, Jing Xu, Fu-Gen Wu*, and Zhi-Wu Yu*. Controllable engineering of asymmetric phosphatidylserine-containing lipid vesicles by calcium cations. Chem. Commun. 2017, 53(95), 12762−12765.

(9) Ge Gao,Yao-Wen Jiang,Jingjing Yang,andFu-Gen Wu*. Mitochondria-targetable carbon quantum dots for differentiating cancerous cells from normal cells. Nanoscale 2017, 9, 18368−18378.

(10) Guang-Yu Pan,# Hao-Ran Jia,# Ya-Xuan Zhu, Ruo-Han Wang, Fu-Gen Wu*, and Zhan Chen*. Dual Channel Activatable Cyanine Dye for Mitochondrial Imaging and Mitochondria-Targeted Cancer Theranostics. ACS Biomater. Sci. Eng. 2017, 3(12), 3596−3606. (Front Cover)

(11) Jingjing Yang,#Ge Gao,#Xiaodong Zhang,Yong-Hao Ma,Hao-Ran Jia,Yao-Wen Jiang,Zhifei Wang*andFu-Gen Wu*. Ultrasmall and photostable nanotheranostic agents based on carbon quantum dots passivated with polyamine-containing organosilane molecules. Nanoscale 2017, 9, 15441−15452.

(12) Liu-Yuan Xia,# Xiaodong Zhang,# Meng Cao, Zhan Chen, and Fu-Gen Wu*. Enhanced Fluorescence Emission and Singlet Oxygen Generation of Photosensitizers Embedded in Injectable Hydrogels for Imaging-Guided Photodynamic Cancer Therapy. Biomacromolecules 2017, 18(10), 3073−3081.

(13) Ningning Ma, Peidang Liu, Nongyue He, Ning Gu, Fu-Gen Wu*, and Zhan Chen*. Action of Gold Nanospikes-Based Nanoradiosensitizers: Cellular Internalization, Radiotherapy, and Autophagy. ACS Appl. Mater. Interfaces 2017, 9(37), 31526−31542.

(14) Yao-Wen Jiang, Ge Gao, Xiaodong Zhang, Hao-Ran Jia, and Fu-Gen Wu*. Antimicrobial carbon nanospheres. Nanoscale 2017, 9, 15786−15795. (Inside Front Cover)

(15) Xian-Wu Hua,# Yan-Wen Bao,# Zhan Chen*, and Fu-Gen Wu*. Carbon quantum dots with intrinsic mitochondrial targeting ability for mitochondria-based theranostics. Nanoscale 2017, 9, 10948−10960.

(16) Ya-Xuan Zhu,# Hao-Ran Jia,#Zhan Chen, and Fu-Gen Wu*. Photosensitizer (PS)/polyhedral oligomeric silsesquioxane (POSS)-crosslinked nanohybrids for enhanced imaging-guided photodynamic cancer therapy. Nanoscale 2017, 9, 12874−12884. (Front Cover)

(17) Hao-Ran Jia, Yao-Wen Jiang, Ya-Xuan Zhu, Yan-Hong Li, Hong-Yin Wang, Xiaofeng Han, Zhi-Wu Yu, Ning Gu, Peidang Liu, Zhan Chen*, and Fu-Gen Wu*. Plasma membrane activatable polymeric nanotheranostics with self-enhanced light-triggered photosensitizer cell influx for photodynamic cancer therapy. J. Control. Release 2017, 255, 231−241.

(18) Hao-Ran Jia,# Ya-Xuan Zhu,# Zhan Chen*, and Fu-Gen Wu*. Cholesterol-Assisted Bacterial Cell Surface Engineering for Photodynamic Inactivation of Gram-Positive and Gram-Negative Bacteria. ACS Appl. Mater. Interfaces 2017, 9(19), 15943−15951.

(19) Ningning Ma, Fu-Gen Wu*, Xiaodong Zhang, Yao-Wen Jiang, Hao-Ran Jia, Hong-Yin Wang, Yan-Hong Li, Peidang Liu, Ning Gu, and Zhan Chen*. Shape-Dependent Radiosensitization Effect of Gold Nanostructures in Cancer Radiotherapy: Comparison of Gold Nanoparticles, Nanospikes, and Nanorods. ACS Appl. Mater. Interfaces 2017, 9(15), 13037−13048.

(20) Xian-Wu Hua,# Yan-Wen Bao,# Hong-Yin Wang, Zhan Chen,* and Fu-Gen Wu*. Bacteria-derived fluorescent carbon dots for microbial live/dead differentiation. Nanoscale, 2017, 9, 2150−2161. (Front Cover)

(21) Jingjing Yang,# Xiaodong Zhang,# Yong-Hao Ma, Ge Gao, Xiaokai Chen, Hao-Ran Jia, Yan-Hong Li, Zhan Chen*, and Fu-Gen Wu*. Carbon Dot-Based Platform for Simultaneous Bacterial Distinguishment and Antibacterial Applications. ACS Appl. Mater. Interfaces 2016, 8(47), 32170−32181.

(22) Ningning Ma, Yao-Wen Jiang, Xiaodong Zhang, Hao Wu, John N. Myers, Peidang Liu, Haizhen Jin, Ning Gu, Nongyue He, Fu-Gen Wu*, and Zhan Chen*. Enhanced Radiosensitization of Gold Nanospikes via Hyperthermia in Combined Cancer Radiation and Photothermal Therapy. ACS Appl. Mater. Interfaces 2016, 8(42), 28480−28494.

(23) Xiaodong Zhang,# Xiaokai Chen,# Jingjing Yang, Hao-Ran Jia, Yan-Hong Li, Zhan Chen,* and Fu-Gen Wu*. Quaternized Silicon Nanoparticles with Polarity-Sensitive Fluorescence for Selectively Imaging and Killing Gram-Positive Bacteria. Adv. Funct. Mater. 2016, 26, 5958−5970. (Front Cover & Highlighted by MaterialsViewsChina)

(24) Hong-Yin Wang,# Xian-Wu Hua,# Hao-Ran Jia, Chengcheng Li, Fengming Lin, Zhan Chen*, and Fu-Gen Wu*. Universal Cell Surface Imaging for Mammalian, Fungal, and Bacterial Cells. ACS Biomater. Sci. Eng. 2016, 2, 987−997. (Highlighted by C&EN: Multifaceted molecule casts a universal glow on cell surfaces)

(25) Hong-Yin Wang, Xian-Wu Hua, Hao-Ran Jia, Peidang Liu, Ning Gu, Zhan Chen, and Fu-Gen Wu*. Enhanced Cell Membrane Enrichment and Subsequent Cellular Internalization of Quantum Dots via Cell Surface Engineering: Illuminating Plasma Membranes with Quantum Dots. J. Mater. Chem. B 2016, 4, 834–843. (Front Cover, 2016 Journal of Materials Chemistry B Hot Paper)

(26) Hong-Yin Wang, Hao-Ran Jia, Xiaolin Lu, Bo Chen, Gaoxin Zhou, Nongyue He, Zhan Chen and Fu-Gen Wu*. Imaging Plasma Membranes without Cellular Internalization: Multisite Membrane Anchoring Reagents Based on Glycol Chitosan Derivatives. J. Mater. Chem. B 2015, 3, 6165–6173. (Back Cover)

(27) Fu-Gen Wu,#,* Xiaodong Zhang,# Siqi Kai,# Mengyi Zhang, Hong-Yin Wang, John N. Myers, Yuxiang Weng, Peidang Liu, Ning Gu, and Zhan Chen*. One-Step Synthesis of Superbright Water-Soluble Silicon Nanoparticles with Photoluminescence Quantum Yield Exceeding 80%. Adv. Mater. Interfaces 2015, 2, 1500360. (Inside Front Cover)

(28) Xiaodong Zhang, Xiaokai Chen, Siqi Kai, Hong-Yin Wang, Jingjing Yang, Fu-Gen Wu* and Zhan Chen*. Highly Sensitive and Selective Detection of Dopamine Using One-Pot Synthesized Highly Photoluminescent Silicon Nanoparticles. Anal. Chem.2015, 87, 3360–3365.

(29) Hong-Yin Wang, Xian-Wu Hua, Fu-Gen Wu,* Bolin Li, Peidang Liu, Ning Gu, Zhifei Wang and Zhan Chen*. Synthesis of Ultrastable Copper Sulfide Nanoclusters via Trapping the Reaction Intermediate: Potential Anticancer and Antibacterial Applications. ACS Appl. Mater. Interfaces 2015, 7, 7082–7092.

(30) Xiaodong Zhang, Fu-Gen Wu,* Peidang Liu, Ning Gu and Zhan Chen*. Enhanced Fluorescence of Gold Nanoclusters Composed of HAuCl4 and Histidine by Glutathione: Glutathione Detection and Selective Cancer Cell Imaging. Small2014, 10, 5170–5177. (Highlighted by MaterialsViewsChina)

招生信息:每年拟招收博士生1-2名,硕士生3-6名(部分学生与国家“千人计划”陈战教授共同指导),本科毕业设计4-6名。希望化学/化工、生物医学工程、医学、生物、材料等专业的学生踊跃报考。联系方式:wufg@seu.edu.cn