吴富根

发布时间: 2013-05-05      访问次数: 12850

 

 

吴富根,男,19839月出生,东南大学生物科学与医学工程学院,生物电子学国家重点实验室,博士,教授,博士生导师。江苏省六大人才高峰高层次人才(2015),江苏省双创人才2016)。

教育工作情况:

2002-2006年,清华大学化学系,理学学士;

2006-2011年,清华大学化学系,理学博士,导师为尉志武教授;

2011-2013年,美国密歇根大学化学系,博士后,导师为Prof. Zhan Chen(陈战教授)。

20132月加入东南大学生物科学与医学工程学院,20134月被评为教授,201312月被评为博士生导师。

研究方向:

(1)细胞表面工程及其在生物医学领域的应用;

(2)针对或基于细胞膜的生物纳米材料或纳米医学材料:制备及其生物医学应用(抗癌、抗菌、成像、生物检测等);

(3)基于细胞自噬、癌细胞耐药性、肿瘤免疫疗法等思路寻找生物材料或生物分子的抗癌新应用。

(4)细胞膜物理化学(相行为、结构、动力学、稳定性等);

研究成果:

发表Adv. Funct. Mater.SmallNanoscaleAdv. Mater. InterfacesACS Biomater. Sci. Eng.ACS Appl. Mater. InterfacesAnal. Chem.J. Mater. Chem. BBioconjugate Chem.J. Phys. Chem. B/CPhys. Chem. Chem. Phys.LangmuirSCI论文60余篇,其中第一/通讯作者论文近40篇(IF均大于3),多篇论文被选为期刊封面文章(包括Adv. Funct. Mater.一次,Nanoscale一次,Adv. Mater. Interfaces一次,J. Mater. Chem. B两次),并被国内外多家网站(包括美国化学工程新闻网站C&ENMaterialsViewsChina,美国Pfizer公司网站、Global Medical Discovery等)和权威综述(包括Chem.Rev.Chem.Soc. Rev.等)重点报道。已申请中国发明专利20余项,已授权6项。2011年获得清华大学优秀博士学位论文奖20142015年连续两年指导本科生获得江苏省优秀本科毕业设计(论文)一等奖(分别为东南大学第12名)。2015年入选东南大学优秀青年教师科学研究资助计划以及江苏省第十二批六大人才高峰高层次人才资助计划,2016年入选江苏省双创人才。主持国家自然科学基金2项(面上项目和青年基金各1项),省部级项目4项,东南大学校级项目3项,参与973863等重大科技项目多项。

  

3年代表性论文(2014-2016):

(1) Xian-Wu Hua,#Yan-Wen Bao,# Hong-Yin Wang, Zhan Chen,* and Fu-Gen Wu.*Bacteria-derived fluorescent carbon dots for microbial live/deaddifferentiation. Nanoscale 2016, DOI: 10.1039/C6NR06558A. (Front Cover)

(2) Jingjing Yang,#Xiaodong Zhang,# Yong-Hao Ma, Ge Gao, Xiaokai Chen, Hao-Ran Jia,Yan-Hong Li, Zhan Chen*, and Fu-Gen Wu*. Carbon Dot-BasedPlatform for Simultaneous Bacterial Distinguishment and AntibacterialApplications. ACS Appl. Mater. Interfaces 2016, DOI:10.1021/acsami.6b10398.

(3) Ningning Ma,Yao-Wen Jiang, Xiaodong Zhang, Hao Wu, John N. Myers, Peidang Liu, Haizhen Jin,Ning Gu, Nongyue He, Fu-Gen Wu*, and Zhan Chen*. EnhancedRadiosensitization of Gold Nanospikes via Hyperthermia in Combined CancerRadiation and Photothermal Therapy. ACS Appl. Mater. Interfaces2016, 8(42), 28480−28494.

(4) Xiaokai Chen,Xiaodong Zhang, Hong-Yin Wang, Zhan Chen,* and Fu-Gen Wu*. SubcellularFate of Fluorescent Cholesterol-Polyethylene Glycol Conjugate: An ExcellentPlasma Membrane Imaging Reagent. Langmuir 2016, 32(39), 10126−10135.

(5) Xiaodong Zhang,#Xiaokai Chen,# Jingjing Yang, Hao-Ran Jia, Yan-Hong Li, Zhan Chen,*and Fu-Gen Wu*. Quaternized Silicon Nanoparticles withPolarity-Sensitive Fluorescence for Selectively Imaging and KillingGram-Positive Bacteria. Adv. Funct. Mater. 2016, 26, 5958−5970. (Front Cover & highlighted by MaterialsViewsChina)

(6) Yao-Wen Jiang,#Hao-Yue Guo,# Zhan Chen, Zhi-Wu Yu, Zhifei Wang, and Fu-GenWu*. In Situ Visualization of Lipid Raft Domains by Fluorescent GlycolChitosan Derivatives. Langmuir, 2016, 32, 6739−6745.

(7) Hong-Yin Wang,#Xian-Wu Hua,# Hao-Ran Jia, Chengcheng Li, Fengming Lin, Zhan Chen*,and Fu-Gen Wu*. Universal Cell Surface Imaging for Mammalian,Fungal, and Bacterial Cells. ACS Biomater. Sci. Eng. 2016, 2016,2, 987−997. (Highlightedby C&EN: Multifaceted molecule casts a universal glow on cell surfaces)

(8) Fu-Gen Wu*, Yao-Wen Jiang,Zhan Chen, and Zhi-Wu Yu*. Folding Behaviors of Protein (Lysozyme) Confined inPolyelectrolyte Complex Micelle. Langmuir 2016, 32, 3655–3664.

(9) Hao-Ran Jia,#Hong-Yin Wang,# Zhi-Wu Yu, Zhan Chen, and Fu-Gen Wu*. Long-TimePlasma Membrane Imaging Based on a Two-Step Synergistic Cell SurfaceModification Strategy. Bioconjugate Chem. 2016, 27, 782–789.

(10) Hong-Yin Wang,Xian-Wu Hua, Hao-Ran Jia, Peidang Liu, Ning Gu, Zhan Chen, and Fu-Gen Wu*.Enhanced Cell Membrane Enrichment and Subsequent Cellular Internalization ofQuantum Dots via Cell Surface Engineering: Illuminating Plasma Membranes withQuantum Dots. J. Mater. Chem. B 2016, 4, 834–843. (Front Cover , 2016Journal of Materials Chemistry B Hot Paper)

(11) Bolin Li,#Hong-Yin Wang,# Peiyong Feng, Xiaofeng Han, Zhan Chen,Xiaolin Lu,* and Fu-Gen Wu*. Qualitative and QuantitativeAnalyses of the Molecular-Level Interaction Between Memantine and Model CellMembranes.J. Phys. Chem. C 2015, 119, 17074–17083.

(12) Hong-Yin Wang,Hao-Ran Jia, Xiaolin Lu, Bo Chen, Gaoxin Zhou, Nongyue He, Zhan Chen and Fu-GenWu*. Imaging Plasma Membranes without Cellular Internalization: MultisiteMembrane Anchoring Reagents Based on Glycol Chitosan Derivatives. J.Mater. Chem. B 2015, 3, 6165–6173. (Back Cover)

(13) Fu-Gen Wu,* Hai-Yuan Sun, YuZhou, Geng Deng and Zhi-Wu Yu*. Molecular-Level Pictures of the Phase Transitionsof Saturated and Unsaturated Phospholipid Binary Mixtures. RSC Adv.2015, 5, 726–733.

(14) Fu-Gen Wu, Yao-Wen Jiang,Hai-Yuan Sun, Jun-Jie Luo, and Zhi-Wu Yu*. Complexation of Lysozyme with SodiumPoly(styrenesulfonate) via the Two-State and Non-Two-State Unfoldings ofLysozyme. J. Phys. Chem. B 2015, 119, 14382–14392.

(15) Fu-Gen Wu,#,* Xiaodong Zhang,#Siqi Kai,# Mengyi Zhang, Hong-Yin Wang, John N. Myers, YuxiangWeng, Peidang Liu, Ning Gu, and Zhan Chen*. One-Step Synthesis of SuperbrightWater-Soluble Silicon Nanoparticles with Photoluminescence Quantum YieldExceeding 80%. Adv. Mater. Interfaces 2015, 2, 1500360. (Inside Front Cover)

(16) Xiaodong Zhang, Fu-GenWu*, Peidang Liu, Hong-Yin Wang, Ning Gu, Zhan Chen*. Synthesis of Ultrastableand Multifunctional Gold Nanoclusters with Enhanced Fluorescence and Potential AnticancerDrug Delivery Application.J. Colloid Interface Sci. 2015, 455,6–15.

(17) Xiaodong Zhang,Xiaokai Chen, Siqi Kai, Hong-Yin Wang, Jingjing Yang, Fu-Gen Wu*and Zhan Chen*. Highly Sensitive and Selective Detection of Dopamine UsingOne-Pot Synthesized Highly Photoluminescent Silicon Nanoparticles. Anal.Chem.2015, 87, 3360–3365.

(18) Hong-Yin Wang,Xian-Wu Hua, Fu-Gen Wu,* Bolin Li, Peidang Liu, Ning Gu, ZhifeiWang and Zhan Chen*. Synthesis of Ultrastable Copper Sulfide Nanoclusters viaTrapping the Reaction Intermediate: Potential Anticancer and AntibacterialApplications. ACS Appl. Mater. Interfaces 2015, 7, 7082–7092.

(19) Xiaodong Zhang, Fu-GenWu,* Peidang Liu, Ning Gu and Zhan Chen*. Enhanced Fluorescence of GoldNanoclusters Composed of HAuCl4 and Histidine by Glutathione:Glutathione Detection and Selective Cancer Cell Imaging. Small2014, 10, 5170–5177. (Highlighted by MaterialsViewsChina)

(20) Fu-Gen Wu*, Pei Yang, ChiZhang, Xiaofeng Han, Minghu Song and Zhan Chen*. Investigation of Drug-ModelCell Membrane Interactions Using Sum Frequency Generation VibrationalSpectroscopy: A Case Study of Chlorpromazine. J. Phys. Chem. C2014, 118, 17538–17548. (Highlighted by Pfizer)

(21) Fu-Gen Wu*, Pei Yang, ChiZhang, Bolin Li, Xiaofeng Han, Minghu Song and Zhan Chen*. MolecularInteractions between Amantadine and Model Cell Membranes. Langmuir2014, 30, 8491–8499. (Selected as Key Scientific Articles by Global MedicalDiscovery)

(22) Fu-Gen Wu, Rui-Guang Wu,Hai-Yuan Sun, Yan-Zhen Zheng and Zhi-Wu Yu*. Demixing and crystallization ofDODAB in DPPC–DODAB binary mixtures. Phys. Chem. Chem. Phys.2014, 16, 15307–15318.

(23) Fu-Gen Wu, Hai-Yuan Sun,Yu Zhou, Rui-Guang Wu and Zhi-Wu Yu*. Full Picture of the Thermotropic Phase Behaviorof Cardiolipin Bilayer in Water: Identification of a Metastable Subgel Phase. RSCAdv. 2014, 4, 51171–51179.

招生信息:每年拟招收博士生1-2名,硕士生3-6名(部分学生与国家千人计划陈战教授共同指导),本科毕业设计4-6名。希望化学/化工、生物医学工程、医学、生物、材料等专业的学生踊跃报考。联系方式:wufg@seu.edu.cn